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Chapter
In Vivo Evidence for and Consequences of Functional Selectivity
Functional selectivity refers to the ability of some ligands to stimulate a subset of the possible consequences of activation of a receptor. This chapter addresses two related issues that are critical for cons...
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Chapter and Conference Paper
Genetically Altered Mice as Models for Understanding Brain Disorders
In an attempt to understand the potential contribution of various neurotransmitter systems to the elaboration of symptoms associated with central nervous systems disorders in humans, we have studied geneticall...
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Chapter
G Proteins and G Protein-Coupled Receptors
Cells live in a constantly changing milieu. The structure and biochemical nature of this environment is dynamic and in order for normal cellular function to proceed in a manner appropriate for the benefit of t...
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Chapter
Monoamine Transporters
Central monoaminergic transmission is controlled by several critical processes. A complex balance between the amount of neurotransmitter synthesized, stored, released, metabolized, and recaptured determines th...
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Chapter
Involvement of Dopamine Transporters in Psychiatric Disorders
The plasma membrane dopamine transporter (DAT) and the vesicular monoamine transporter (VMAT2) are key regulators of dopamine neurotransmission. DAT acts to terminate the actions of dopamine by rapidly removin...
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Chapter
Interactions of Dopamine Receptors with G Proteins
Dopamine is an important neurotransmitter, playing roles in motor control, emotion and affect, neuroendocrine regulation, and regulation of sodium uptake in the kidney, among other functions. The receptors for...
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Chapter
Receptor-G Protein-Effector Coupling: Coding and Regulation of the Signal Transduction Process
Regulation of G protein mediated signal transduction is thought to occur primarily as the result of the occupancy of a receptor by the appropriate agonist. There is much regulation of this process, however, wh...
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Chapter
Structural, Functional, and Genetic Aspects of Receptors Coupled to G-Proteins
A remarkably diverse array of biologically active substances elicit their actions by interacting with Cell surface receptors which are coupled via guanine nucleotide regulatory proteins (G-proteins) to specifi...
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Chapter
Structure-Function Relationships
Understanding, in molecular terms, the ways in which extracellular signals are transduced across the cell membrane so as to modify key intracellular metabolic processes ultimately requires that the various ele...
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Chapter
Structure and Function of the Adrenergic Receptor Family
The interaction of hormones and drugs with their respective targets has been widely studied with the hope that a better understanding of the molecular basis of their actions would provide insights not only int...
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Chapter
D1 and D2 Dopamine Receptors: Identification by Photoaffinity Labeling and Purification by Affinity Chromatography
In an attempt to characterize the receptors which mediate the physiological actions of dopamine, we have developed several probes for the characterization of both the D1 and D2 subtypes of dopamine receptors. To ...
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Chapter
Biochemical Properties of D1 and D2 Dopamine Receptors
The physiological action of dopamine are mediated by two distinct subtypes of receptors, D1 and D2 dopamine receptors. D1-receptors are linked to stimulation of adenylate cyclase whereas D2-receptors inhibit the ...
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Chapter
Isolation And Biochemical Characterization Of The D1 And D2 Dopamine Receptors
The catecholamine, dopamine, exerts physiologic effects in both the central nervous system and the periphery. Dopamine systems in the central nervous system (CNS) have been implicated in several neurologic and...
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Chapter
The β-Adrenergic Receptor Kinase: Role in Homologous Desensitization in S49 Lymphoma Cells
Phosphorylation of the β-adrenergic receptor (BAR) is closely associated with homologous desensitization of the B-adrenergic receptor-coupled adenylate cyclase system. Homologous desensitization and receptor p...
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Chapter
Regulation of the Adenylate Cyclase Signalling Pathway: Potential Role for the Phosphorylation of the Catalytic Unit by Protein Kinase A and Protein Kinase C
We have investigated the phosphorylation of the pure catalytic unit of adenylate cyclase by cyclic AMP-dependent protein kinase (PKA) and Ca2+/phospholipid-dependent protein kinase (PKC). The catalytic unit of ad...
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Chapter
Molecular Mechanisms of β-Adrenergic Receptor Desensitization
Desensitization or adaptation is well known in biological regulation. Also referred to as tachyphylaxis, tolerance or refractoriness, it is most commonly observed as a loss of cellular responsiveness to a neur...
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Chapter
The β-Adrenergic Receptor:Elucidation of Its Molecular Structure
Neurotransmitters and drugs interact with specific receptors in order to produce a cellular response. This recognition of specific agonists by receptors is the first step in an amplification process resulting ...
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Chapter
Membrane-Bound Hormone Receptors
Receptors are those cellular structures with which biologically active hormones and drugs first interact. Physiologically these receptors perform two essential functions. The first is that of recognition of a ...