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Resistance of Brain Tumours to Chemotherapy: Preliminary Studies of Rat and Human Tumours

There are several possible reasons why malignant brain tumours do not respond to chemotherapy. First, because of impaired drug delivery, chemotherapeutic agents might not reach all tumour cells in cytoxic conc...

M. L. Rosenblum, D. F. Deen, V. A. Levin, D. V. Dougherty… in Modern Neurosurgery 1 (1982)