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    Chapter

    Preclinical Pharmacodynamics of Central Nervous System Active Agents

    In preclinical drug development power spectral analysis of drug induced changes in the electroencephalogram (EEG) is often used to characterize the pharmacological properties of new psychotropic drugs. In this...

    M. Danhof, J. W. Mandema, A. Hoogerkamp in Integration of Pharmacokinetics, Pharmacod… (1993)

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    Chapter

    Determination of Benzodiazepines: The Present-Day Scene

    Methods that have been used for determining benzodiazepines in biological fluids include GC, HPLC, direct DPP, RIA and RRA methods*, of which GC, HPLC and RRA have proved the most valuable in clinical research...

    M. Danhof, J. Dingemanse, D. D. Breimer in BIOACTIVE ANALYTES, Including CNS Drugs, P… (1986)

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    Chapter

    Urinary metabolite profile of antipyrine as a tool in the assessment of oxidative drug metabolizing capacity of man

    It is a well-established phenomenon that great differences in intensity and duration of drug response may arise between individual patients when the same dose of a drug is given to each patient. Such interindi...

    M. Danhof, D. D. Breimer in Methods in Clinical Pharmacology (1980)