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Chapter
Regulatory T-Cell Differentiation and Their Function in Immune Regulation
Regulatory T-cells (Treg) represent a subset of CD4+ T-cells characterized by high suppressive capacity, which can be generated in the thymus or induced in the periphery. The deleterious phenotype of the Scurf...
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Chapter
Reconstructing Transcriptional Networks Using Gene Expression Profiling and Bayesian State-Space Models
A major challenge in systems biology is the ability to model complex regulatory interactions. This chapter is concerned with the use of Linear- Gaussian state-space models (SSMs), also known as linear dynamica...
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Chapter
Estrogen-Stimulated, Membrane-Initiated Receptor-Ligand Interactions in Vascular Cells
17β-estradiol(E2)is thought to play a pivotal role in regulating female cardiovascular, skeletal, and mental health. The vascular endothelium is a continuous cellular monolayer which forms the luminal lining a...
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Chapter
The Role of the p35/cdk5 Kinase in Cortical Development
Extensive studies on the mouse mutant reeler have revealed many of the fundamental characteristics of neocortical development (Caviness and Rakic 1978; Caviness 1982; Caviness et al. 1988). The finding of another...