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    Chapter

    Regulatory T-Cell Differentiation and Their Function in Immune Regulation

    Regulatory T-cells (Treg) represent a subset of CD4+ T-cells characterized by high suppressive capacity, which can be generated in the thymus or induced in the periphery. The deleterious phenotype of the Scurf...

    Miranda Piccioni, Zuojia Chen, Andy Tsun in T Helper Cell Differentiation and Their Fu… (2014)

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    Chapter

    Reconstructing Transcriptional Networks Using Gene Expression Profiling and Bayesian State-Space Models

    A major challenge in systems biology is the ability to model complex regulatory interactions. This chapter is concerned with the use of Linear- Gaussian state-space models (SSMs), also known as linear dynamica...

    Matthew J. Beal, Juan Li, Zoubin Ghahramani in Introduction to Systems Biology (2007)

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    Chapter

    Estrogen-Stimulated, Membrane-Initiated Receptor-Ligand Interactions in Vascular Cells

    17β-estradiol(E2)is thought to play a pivotal role in regulating female cardiovascular, skeletal, and mental health. The vascular endothelium is a continuous cellular monolayer which forms the luminal lining a...

    Li Lei, M. Page Haynes, Jeffrey R. Bender in The Identities of Membrane Steroid Receptors (2003)

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    Chapter

    The Role of the p35/cdk5 Kinase in Cortical Development

    Extensive studies on the mouse mutant reeler have revealed many of the fundamental characteristics of neocortical development (Caviness and Rakic 1978; Caviness 1982; Caviness et al. 1988). The finding of another...

    Young T. Kwon, Li-Huei Tsai in Mouse Brain Development (2000)