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Nanodesigned Pore-Containing Systems for Biosensing and Controlled Drug Release
For medical treatment of disease, optimal therapeutic efficiency of a drug is governed by both the therapeutic activity of the drug itself and the way in which it is delivered to the patient. Once administered...
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Microscale Flow and Transport Simulation for Electrokinetic and Lab-on-Chip Applications
The proliferation of manufacturing techniques for building micro- and nano-scale fluidic devices has led to a virtual explosion in the development of microscale chemical and biological analysis systems, common...
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Chapter
BioMEMS for Cellular Manipulation and Analysis
Since the introduction of Micro-electro-mechanical systems in the early 70’s, the significance of the biomedical applications of these miniature systems has been realized [54, 77]. BioMEMS, the abbreviation for B...
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Evaluation of the Reliability of cDNA Microarray Technique
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Chapter
Fast Screening of Single-Nucleotide Polymorphisms Using Chip-Based Temperature Gradient Capillary Electrophoresis
Recently, the analysis of single-nucleotide polymorphisms has attracted much attention. Although many techniques have been reported, new methods with high resolving power, low-cost and fast speed are still in ...
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Chapter
Photoactivatable Silanes: Synthesis and Uses in Biopolymer Array Fabrication on Glass Substrates
We wish to report a fast and easy way to build hydrophobic layers and hydrophilic functional polymer layers thereafter onto glass surfaces. A benzophenone-based silane was synthesized and used to prepare stabl...
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Chapter
An Integrated Biochemoinformatics System for Drug Discovery
Chipscreen Biosciences, Ltd. (www.chipscreen.com) is a drug discovery company specialized in novel small molecule therapeutics. Chipscreen has developed a proprietary chemical genomics approach to accelerate t...
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Chapter
Cellular to Tissue Informatics: Approaches to Optimizing Cellular Function of Engineered Tissue
Tissue engineering is a rapidly expanding, multi-disciplinary field in biomedicine. It provides the ability to manipulate living cells and biomaterials for the purpose of restoring, maintaining, and enhanc...
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Electronic Biosensors Based on DNA Self-Assembled Monolayer on Gold Electrodes
Information concerning the immobilization and hybridization of DNA on a surface is paramount to the development of DNA-based electronic biosensors. This study looks at recent investigations of DNA immobilized ...
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Chapter
Improvement of Microarray Technologies for Detecting Single Nucleotide Mismatch
With the completion of the Human Genome Project and beginning of post genome era, there is an urgent need for a fast, specific, sensitive, reliable and cost-effective method for the genome-wide polymorphism an...
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Chapter
Biomolecular Sensing for Cancer Diagnostics Using Carbon Nanotubes
The field of biomolecule sensing in the medical field is broad and rapidly evolving. The devices range in size from microns to centimeters across the sensing surface and rely on electronic, optical or other fo...
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Chapter
NMR Spectroscopy of Tumors
Magnetic resonance imaging is widely employed in the clinical detection of cancer. Discrimination of tumors from surrounding normal tissues is based on differences in relaxation times, which are usually longer...