36 Result(s)
within
Biomedicine
Biotechnology
Lu**g Li
Chapter
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Chapter
Monoclonal Antibodies: From Structure to Therapeutic Application
The exciting field of therapeutic monoclonal antibodies (mAbs) had its origins when Köhler and Milstein presented their murine hybridoma technology in 1975 (Kohler, Milstein. Nature. 256(5517):495–497, 1975). ...
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Animal Models of Tuberculosis
Tuberculosis (TB) is an important zoonotic disease caused by infection with Mycobacterium tuberculosis (Mtb) complex and has a significant impact on public health. Animal models are suitable tools to mimic the cl...
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Correction to: Therapeutics and Diagnostics Discovery
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Therapeutics and Diagnostics Discovery
In any therapeutics discovery and development effort, multiple critical steps must be accomplished to arrive at a compound that is safe and efficacious, while also exhibiting the complex array of desired drug-...
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New Alternative Methods in Drug Safety Assessment
In the past few decades, despite advancements in biomedical research, the success rate of bringing a new drug candidate to the market has been very low. Additionally, over the same time period, some approved d...
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Surface Modification of Metallic Biomaterials for Cardiovascular Cells Regulation and Biocompatibility Improvement
Interaction of cells and the metallic biomaterials usually happened at the materials’ surface and interface, which often decides the biocompatibility and further application of the medical devices. Clinically,...
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Advances in 3D Vascularized Tumor-on-a-Chip Technology
Tumors disrupt the normal homeostasis of human body as they proliferate in abnormal speed. For constant proliferation, tumors recruit new blood vessels transporting nutrients and oxygen. Immune system simultan...
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Strategies to Optimize Peptide Stability and Prolong Half-Life
Peptide drugs represent 5% of the global pharmaceutical market, but growing twice as fast as the rest of the drug market. The development of peptide therapeutics is challenging due to their low stability, shor...
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Overview of the Impact of Protein Interfacial Instability on the Development of Biologic Products
Interfacial phenomena can significantly affect the development, manufacturing, stability, and use of therapeutic proteins. Proteins are exposed to air-liquid, solid-liquid, and liquid-liquid interfaces through...
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Biorhythms of Hens
The study of biorhythms, which are internal responses to external stimuli, is knows as chronobiology. Biorhythms, and their impact on physiological processes, exist across a wide range of different species. He...
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Stimuli Responsive Imprinted DDS
Molecularly imprinted polymers (MIPs) are expected as new generations of intelligent and self-regulated drug delivery systems (DDS). Their huge potential based on molecular recognition could bring about intell...
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Future Perspectives
In this chapter, we describe future perspectives of product development of biologics with an emphasis on the effect of interfacial stress on product performance and development, including analytical detection,...
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The Application of DNA Nanostructures in Vaccine Technology
Vaccine is a biological agent for preventing and curing disease, which inducts both innate and adaptive immune mechanism to be effective. Facing potentially unknown pathogens, the current vaccine technologies ...
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MIP as Drug Delivery Systems for Special Application
The precisely controlled release of the loaded template drugs to target has been achieved using polymeric materials as drug delivery systems. Molecularly imprinted polymers (MIPs), which capture target molecul...
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Levoglucosan Production by Fast Pyrolysis of Biomass After Dilute Acid Pretreatment
Fermentable sugars are valuable intermediates that can be produced from lignocellulosic biomass, in which hemicellulose and cellulose are favorable candidates for their production. In this chapter, the adaptab...
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Isolation, Purification, and Potential Applications of Xylan
There is great interest in replacing fossil fuel resources with renewable raw materials. Widely distributed lignocellulosic biomass is viewed as a potential candidate to address energy and environmental demand...
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Efficient Test for Nonlinear Dependence of Two Continuous Variables
A new method to test nonlinear dependence between two continuous variables (X and Y) is proposed. This is achieved by using continuous analysis of variance (CANOVA). The software is available at
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Introduction to Characterization Methods for Heterogeneous Catalysts and Their Application to Cellulose Conversion Mechanisms
To realize large-scale commercialization of cellulose conversion, design of catalysts based on understanding of their structure and detailed mechanisms are needed. Characterization methods for heterogeneous ca...
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Fundamentals of Bifunctional Catalysis for Transforming Biomass-Related Compounds into Chemicals and Biofuels
Multi-step catalytic processes are generally required in chemoselective conversion of biomass derivatives into chemical products. Integration of different types of transformations into a single catalytic syste...
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Mycorrhiza: Creating Good Spaces for Interactions
Soil is a complicate environment, where complex systems of multiple interactions between the organisms take place. Plant health is majorly determined by these vital interactions in the soil. The ubiquitous arb...
