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  1. No Access

    Chapter

    Recombinant Human Hepatocyte Growth Factor Promotes Functional Recovery After Spinal Cord Injury

    Hepatocyte growth factor (HGF), which is a potent mitogen for mature hepatocytes and a mediator of the inflammatory responses to tissue injury, was recently highlighted as a potent neurotrophic factor in the c...

    Kazuya Kitamura, Akio Iwanami… in Neuroprotection and Regeneration of the Sp… (2014)

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    Chapter

    Targeting Chemotherapy of Peritoneally Disseminated Gastric Cancer with Monoclonal Antibody-Drug Conjugates

    Monoclonal antibody A7 was produced by a hybridoma generated by the fusion of splenocytes from a mouse immunized against human colon carcinoma cells and murine myeloma P3.X63.Ag8.653 cells by Kotanagi et al. [1]....

    Toshiharu Yamaguchi, Kazuma Okamoto… in Multimodality Therapy for Gastric Cancer (1999)

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    Chapter and Conference Paper

    Targeting Chemotherapy for Digestive Cancer Using Monoclonal Antibody Drug Conjugate

    Murine monoclonal antibody A7 against human colon cancer was conjugated with the anticancer agent Neocarzinostatin (NCS) to form the conjugate A7-NCS. Using this conjugate, immunotargeted chemotherapy, (missil...

    Toshio Takahashi, Toshiharu Yamaguchi… in Recent Advances in Management of Digestive… (1993)

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    Chapter and Conference Paper

    Enhanced Antitumor Effect of Neocarzinostatin Conjugated to Monoclonal Antibody A7 on Human Pancreatic Carcinoma Grafted in Nude Mice

    Recent research has been directed toward the use of monoclonal antibody-drug conjugates for solid tumors. In this study, we used the monoclonal antibody A7 to target the antitumor drug neocarzinostatin (NCS) t...

    Eigo Otsuji, Toshiharu Yamaguchi… in Recent Advances in Management of Digestive… (1993)

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    Chapter and Conference Paper

    A New Chemotherapy to Reduce The Local Recurrence of Rectal Cancer

    This report investigates the application of monoclonal antibody A7 and its drug conjugate ininhibiting the local recurrence of rectal cancer. The experimental protocol consisted of local retension, lymphatic d...

    Kazuya Kitamura, Toshio Takahashi… in Recent Advances in Management of Digestive… (1993)

  6. No Access

    Chapter and Conference Paper

    Radioimmunoimaging of Local Recurrence of Rectal Cancer by Radiolabeled Mouse Monoclonal Antibody A7

    Though the definite diagnosis of local recurrence of rectal carcinoma is still difficult, recent rapid development of new diagnostic tools such as ultrasonography, X-ray CT and MRI brought us many information ...

    Toshiharu Yamaguchi, Takuya Miyagaki… in Recent Advances in Management of Digestive… (1993)