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Chapter
LH Hypersecreting Mice: A Model for Ovarian Granulosa Cell Tumors
Proper function of the ovary requires carefully orchestrated proliferation and differentiation of granulosa cells that respond dynamically to signals from LH and FSH, and a host of other paracrine and autocrin...
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Chapter and Conference Paper
The α-Subunit of the Glycoprotein Hormones: Evolution of a Combinatorial Code for Placenta-Specific Expression
Luteinizing hormone (LH), follicle stimulating hormone (FSH), thyroid stimulating hormone (TSH), andchorionic gonadotropin (CG) belong to a family of glycoprotein hormones. Each member is compose...
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Chapter
Molecular Mechanisms Underlying Placenta- and Pituitary-Specific Expression of the Glycoprotein Hormone α-Subunit Gene
All vertebrates synthesize three different pituitary glycoprotein hormones: luteinizing hormone (lutropin, LH), follicle stimulating hormone (folli-tropin, FSH), and thyroid stimulating hormone (thyrotropin, TSH)...
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Chapter and Conference Paper
Expression by Transgenic Mouse Placenta of a Human Placental Hormone, the β-Subunit of Human Chorionic Gonadotropin
Chorionic gonadotropin (CG) is a member of a family of glycoprotein hormones that includeslutropin (LH), follitropin, and thyrotropin. The 4 hormones are heterodimers with a common α-subunit and ...
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Chapter
Estradiol Inhibition of Expression of the Human Glycoprotein Hormone α-Subunit Gene Through an ERE-Independent Mechanism
The α-subunit comprises one-half of all glycoprotein hormones. Expression of the α-subunit gene occurs in a variety of cell types (gonadotrophs, thyrotrophs, and syncytiotrophoblasts) and is regulated by a mul...