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Chapter
Sleep in Prenatally Restraint Stressed Rats, a Model of Mixed Anxiety-Depressive Disorder
Prenatal restraint stress (PRS) can induce persisting changes in individual’s development. PRS increases anxiety and depression-like behaviors and induces changes in the hypothalamo–pituitary–adrenal (HPA) axi...
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Chapter
A Self-Medication Hypothesis for Increased Vulnerability to Drug Abuse in Prenatally Restraint Stressed Rats
Stress-related events that occur in the perinatal period can permanently change brain and behavior of the develo** individual and there is increasing evidence that early-life adversity is a contributing fact...
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Chapter
Behavioural and Neuroendocrine Consequences of Prenatal Stress in Rat
Chronic hyperactivation of the hypothalamus–pituitary axis is associated with the suppression of reproductive, growth, thyroid and immune functions that may lead to various pathological states. Although many i...