18 Result(s)
within
Chapter
Irving L. Weissman
-
Chapter
Urochordata: Botryllus – Natural Chimerism and Tolerance Induction in a Colonial Chordate
Chimerism is defined as the coexistence of two or more genomes of separate origin within an individual. In placental mammals such as humans, natural chimerism develops during pregnancy between a mother and fet...
-
Chapter
Stem Cells, Chimerism and Tolerance: Lessons from Mammals and Ascidians
Chimerism is the presence of cells derived from more than one individual in a given individual. This phenomenon has been detected in a wide variety of multicellular organisms, including vertebrates. In mammals...
-
Chapter and Conference Paper
Leukemia and Leukemic Stem Cells
Leukemias are cancers of the hematopoietic system. Like all cancers, several genetic and epigenetic events aid in the transition from normal to malignant cell. These usually, if not always, include at least: 1...
-
Chapter
Formation and Differentiation of Leukocytes
Inflammatory responses often involve the selective accumulation in tissues of complex mixtures of leukocytes. In order to understand the processes governing migration and accumulation of mature leukocytes, it ...
-
Chapter
T-Cell Development from Hematopoietic Stem Cells
The central cells of the immune system include three major populations of lymphocytes with distinct antigen recognition receptors: T-cells, B-cells, and natural killer (NK) cells. All lymphocyte populations, a...
-
Chapter
Detection of Specific mRNAs by In Situ Hybridization
All glassware should be baked at ⊖ 200°C overnight All solutions, except those containing Tris, should be treated with diethylpyrocarbonate (Sigma, D-5758) for at least 2 hr and then autoclaved. Gloves should ...
-
Chapter
The Granzyme A Gene: A Marker for Cytolytic Lymphocytes In Vivo
Granzyme A, initially termed Hanukkah factor (HF) in this laboratory, is a serine protease contained within specialized cytoplasmic granules of activated cytolytic lymphocytes (CTL). These granules contain oth...
-
Chapter
Retreat Growth in the Ascidian Botryllus Schlosseri: A Consequence of Nonself Recognition
In the genus Botryllus fusion between genetically distinct individuals is controlled by a single genetic locus (or haplotype) with multiple codominantly expressed alleles. Colonies which do not share an allele at...
-
Chapter
Speculations on the Relationships of Two Botryllus Allo-Recognition Reactions—Colony Specificity and Resorption—To Vertebrate Histocompatibility
The objective of this essay is to consider functions of the vertebrate major histocompatibility complex (MHC), especially in comparison to allorecognition in colonial tunicates. Elsewhere Burnet (1971), and ou...
-
Chapter
Lymphocyte Homing Receptors, Ubiquitin, and Cell Surface Proteins
The immune system, unlike most organ systems that are consolidated in one anatomic location, is dispersed over an entire organism. It exists as circulating elements in the blood, through which it gains access ...
-
Chapter
Structural Characterization of a Murine Lymphocyte Homing Receptor Suggests a Ubiquitinated Branched-Chain Glycoprotein
Partial amino acid sequence analysis of a purified lymphocyte homing receptor demonstrates the presence of two amino-termini, one of which corresponds precisely to the amino-terminus of ubiquitin. This observa...
-
Chapter
Thymus Homing Clonogenic Bone Marrow Cells
The thymus plays a major role in guiding the maturation, differentiation and specificity of T cells (1–4), In the adult mouse, the thymus receives small numbers of T cell precursors from the bone marrow and ex...
-
Chapter
Selective Migration of Murine Lymphocytes and Lymphoblast Populations and the Role of Endothelial Cell Recognition
We have examined the organ specificity of migration of three major subpopulations of mature small lymphocytes in the mouse — B cells, the Ly-2- and Lyt-2+ T cells. It is shown that difference in the distribution ...
-
Chapter
The Principal Cells in the Thymus Expressing MHC Antigens are Epithelial
In general, peripheral T cells recognize foreign antigens only in the context of self MHC antigens. This MHC restriction has been shown, at least in some cases, to be determined by radio resistant elements wit...
-
Chapter
Retrovirus Lymphomagenesis: Relationship of Normal Immune Receptors to Malignant Cell Proliferation
In our view the central lesion in oncogenesis is the sustained, apparently uncontrolled proliferation of malignant cells beyond the regulated number of their normal counterparts. In general, therefore, the pro...
-
Chapter
Expression of T Cell Antigens by Cells in Mouse and Human Primary and Secondary Follicles
Peripheral lymphoid organs are divided into predominantly B cell domains (primary and secondary follicles) and T cell domains (lymph node paracortex in spleen periarteriolar sheath). Occasional T cells have be...
-
Chapter
The Role of MuLV Receptors on T-Lymphoma Cells in Lymphoma Cell Proliferation
The induction of thymic lymphocytic neoplasms in mice by murine leukemia viruses (MuLV) involves a complex series of interactions between endogenous retroviral gene sequences and target cells in the thymus (Ka...
-
Chapter
Differentiation of thymus cells
The process of cellular differentiation in the thymus presumably leads to the development of immunocompetent peripheral “T” lymphocytes (1, 6). Although there are considerable data showing the existence of a s...
