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Chapter
Peptidomimetic tyrosine kinase inhibitors induce non apoptotic, Clarke-III type programmed cell death
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Chapter
Further Studies of the Signaling Mechanisms of the Antitumor Somatostatin Analogue TT-232
The somatostatin structural analogue TT-232 is a heptapeptide of a cyclopenta-ring structure: D-Phe-Cys-Tyr-D-Thr-Lys-Cys-Thr-NH2 that was shown to have strong antiproliferative and apoptotic effects on tumor cel...
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Chapter
New Antiproliferative Agents from a Peptidomimetic Library
It is known that chiral ATP analogue quinazolines show selective Epidermal Growth Factor Receptor Tyrosine Kinase (EGFR TK) inhibitory activity depending on the chirality of the molecule [1]. We have developed...
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Chapter
HPLC Analysis, Modeling, and Biological Studies of Antiproliferative Heterocyclic Carboxamides
Reversed phase HPLC and MEKC [1] provide excellent possibilities to measure the hydrophobic properties of compounds, characterizing them directly from the chromatographic retention time. The aim in this respec...