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  1. No Access

    Chapter

    Biodegradation of Luteinizing Hormone-Releasing Hormone

    The concept that the proteolytic degradation of peptide hormones could be one of the key mechanisms regulating the homeostasis of the hormone, as proposed by Knights et al. (1973), is widely accepted. However, cu...

    Károly Nikolics, György Kéri, Balázs Szöke… in Hormonally Active Brain Peptides (1982)

  2. No Access

    Chapter

    Tritium Labeling of Brain Peptides

    During the past decade, radiolabeling of biologically active peptides has become a widely applied and essential technique for a variety of biochemical and physiological investigations.

    István Teplán, Imre Mező, Károly Nikolics… in Hormonally Active Brain Peptides (1982)

  3. No Access

    Chapter

    Further Studies of the Signaling Mechanisms of the Antitumor Somatostatin Analogue TT-232

    The somatostatin structural analogue TT-232 is a heptapeptide of a cyclopenta-ring structure: D-Phe-Cys-Tyr-D-Thr-Lys-Cys-Thr-NH2 that was shown to have strong antiproliferative and apoptotic effects on tumor cel...

    Attila Steták, Tibor Vántus, Gyöngyi Bökönyi… in Peptides: The Wave of the Future (2001)

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    Chapter

    New Antiproliferative Agents from a Peptidomimetic Library

    It is known that chiral ATP analogue quinazolines show selective Epidermal Growth Factor Receptor Tyrosine Kinase (EGFR TK) inhibitory activity depending on the chirality of the molecule [1]. We have developed...

    László Őrfi, Györgyi Bökönyi, Anikó Horváth… in Peptides: The Wave of the Future (2001)

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    Chapter

    HPLC Analysis, Modeling, and Biological Studies of Antiproliferative Heterocyclic Carboxamides

    Reversed phase HPLC and MEKC [1] provide excellent possibilities to measure the hydrophobic properties of compounds, characterizing them directly from the chromatographic retention time. The aim in this respec...

    János Seprõdi, Ferenc Hollósy, Dániel Erõs, László Õrfi… in Peptides: The Wave of the Future (2001)

  6. No Access

    Chapter

    Peptidomimetic tyrosine kinase inhibitors induce non apoptotic, Clarke-III type programmed cell death

    György Kéri, László Ôrfi, Gergely Szántó… in Peptides Frontiers of Peptide Science (2002)