8 Result(s)
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E. Antonio Chiocca
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Local Therapies
Local therapies in the context of cranial tumor encompass the concept of local application or local delivery, respectively. Apart from surgical resection which is the most obvious form of local therapy, radiat...
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Intraoperative MRI (ioMRI) in the Setting of Awake Craniotomies for Supratentorial Glioma Resection
Both awake craniotomy under conscious sedation and use of intraoperative MRI can increase the efficiency and safety of glioma resections. In contrast to craniotomies under general anesthesia, neurosurgery unde...
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Herpes Simplex Virus 1 for Cancer Therapy
The obvious inadequacy of conventional therapies to combat cancer has spawned the development of a variety of nonconventional treatment modalities such as cancer-specific replication competent viruses. Herpes ...
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Clinical Trials of Oncolytic Viruses for Gliomas
There has been resurgent interest in the use of mutant or genetically engineered strains of viruses for the local treatment of gliomas. The clinical status of these agents is reviewed and further progress in t...
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Experimental and Clinical Gene Therapies for Brain Tumors
Experimental treatments employing viruses as antitumor agents were initially described in 1912, when vaccination with rabies virus was thought to have produced the disappearance of a large cervical carcinoma (1)....
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Virus-Mediated Genetic Treatment of Rodent Gliomas
The most common primary central nervous system neoplasm in adults is the malignant glioma. Approximately 5,000 new cases are diagnosed annually in the United States. This tumor has proven to be extremely refra...
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Transglutaminases and Their Regulation: Implications for Polyamine Metabolism
Transglutaminases are a group of enzymes that catalyze the posttranslational modification of protein-bound glutamine residues. It appears that the major physiological role of these enzymes is to crosslink prot...
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Retinoid — Regulated Expression of Tissue Transglutaminase in Normal and Leukemic Myeloid Cells
Transglutaminases are a group of enzymes that catalyze the covalent cross-Unking of proteins by facilitating the formation of ε-(γ-glutaminyl)-lysyl isopeptide bonds between protein-bound glutamine and lysine ...
