6 Result(s)
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Chapter
David M. Jablons
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Chapter
Lung Cancer Staging and Prognosis
The seventh edition of the non-small cell lung cancer (NSCLC) TNM staging system was developed by the International Association for the Staging of Lung Cancer (IASLC) Lung Cancer Staging Project by a coordinat...
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Chapter
Lung Cancer Stem Cells
Lung cancer remains the leading cause of cancer mortality and novel therapies are desperately needed to treat metastatic and recurrent disease. The cancer stem cell hypothesis is based on data that within each...
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Hallmarks of Metastasis
Metastasis is rarely due to accidental sloughing off of cancerous cells from a nonmalignant tumor and colonizing elsewhere; on the contrary, it is an active process requiring genetic and/or epigenetic mechanis...
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Chapter
The Pro-inflammatory Milieu and Its Role in Malignant Epithelial Initiation
Increasing research from preclinical and clinical studies is demonstrating that inflammation with its myriad of heterogeneous mediators and cellular effectors plays a role in the malignant initiation of epithe...
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Chapter
Wnt Signaling in Cancer: From Embryogenesis to Stem Cell Self-Renewal
Over the years, the role of the Wingless-int (Wnt) signaling pathway during embryogenesis has been the focus of many researchers, its role being fundamental for physiological organogenesis. More recently, duri...
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Chapter
Stem Cells and Lung Cancer
Lung cancer with its more than 1 million deaths per year is the leading cause of cancer mortality for both men and women worldwide. Despite recent advances in current treatment modalities, overall survival rat...
