17 Result(s)
within
English
Human Genetics
C. Muller
Chapter
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Chapter and Conference Paper
Mutant Cell Lines as Means of Resolving HLA Gene Products
Mutants of lymphoblastoid cell lines have helped to identify, dissect, and locate genes of defined HLA products particularly within the HLA-D region [1], They can be used to characterize still unknown human MH...
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Chapter and Conference Paper
HLA-A, B, C Monoclonal Antibodies
Since Köhler and Milstein (1975) perfected the hybridroma technique, it has been possible to produce monoclonal antibodies (Mo Abs) which react against antigens of the human MHC. This technology allowed the pr...
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Chapter and Conference Paper
Defective Expression of HLA-D-Region Determinants in Children with Congenital Agammaglobulinemia and Malabsorption: A New Syndrome
Recently we have described four children with congenital AG associated with persistent diarrhea, malabsorption, and failure to thrive [5, 6]. All patients displayed a lack of expression of HLA-DR and DQ antige...
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Chapter and Conference Paper
Enhancing Monoclonal Antibodies Against HLA-Bw4 Molecules
The relationship of antigenic determinants on HLA-Bw4-bearing molecules has been analyzed by means of the monoclonal antibodies (MOABs) TÜ48 (IgM), TÜ109 (IgG) and TÜ110 (IgG). TÜ48 [1] and TÜ109 [C. Müller et...
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Chapter and Conference Paper
RFLP Standardization Report for 210H/MspI
The 210H/MspI system identified six standard fragments in the core cell lines as shown in Table 1 and Figure 1. Much of the data received for this system was difficult to interpret because all the fragments we...
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Chapter and Conference Paper
RFLP Standardization Report for C4/MspI
The panel of core cell lines cut with restriction enzyme MspI and hybridized with the C4 probe revealed a very simple pattern (Fig. 1). Two fragments were identified, of which only the first was polymorphic (1...
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Chapter and Conference Paper
RFLP Standardization Report for Class I/MspI
The class I/MspI system showed extensive polymorphism, identifying 21 fragments on the core cell lines (Table 1 and Fig. 1). However, the large number of bands made interpretation of the data difficult despite...
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Chapter and Conference Paper
RFLP Standardization Report for DP Alpha/MspI
The DP alpha/MspI system was found to be relatively polymorphic, identifying 11 standard fragments in the core cell lines as shown in Figure 1 (band number 11 not shown). Fragment number 9 (1.02 kb) was the on...
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Chapter and Conference Paper
RFLP Standardization Report for BF/MspI
The Bf/MspI system identified a simple pattern of three fragments (Table 1). Standard fragments 1 and 2 were constant throughout the core cell lines. Fragment 3 was found to be polymorphic, but of low molecula...
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Chapter and Conference Paper
RFLP Standardization Report for DR Alpha/MspI
Three standard bands were recognized in the DR alpha/MspI system (Table 1 and Fig. 1). The resolution of fragments 1 and 2 on some autoradiographs was not good enough to allow easy interpretation producing dis...
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Chapter and Conference Paper
RFLP Standardization Report for C2/MspI
The C2/MspI system identified three standard fragments in the core cell lines (Fig. 1 and Table 1). Fragments 1 (2.30 kb) and 2 (1.79 kb) were found to be polymorphic, while fragment 3 (1.53 kb) was constant. ...
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Chapter and Conference Paper
RFLP Standardization Report For DQ Alpha/MspI
The core cell lines revealed 11 standard fragments in the DQ alpha/Msp1 system as shown in Figure 1. A fragment between standard bands 4 and 5 (at approximately 5.19 kb) has been reported by some laboratories,...
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Chapter and Conference Paper
Antigen Society #15 Report (Bw4 and Bw6)
During the Tenth Workshop, 27 anti-sera in the Antigen Society and 22 anti-sera in the Core serology serum set were provided for the serologic analysis of the supertypic HLA-B locus specificities Bw4 and Bw6. ...
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Chapter and Conference Paper
RFLP Standardization Report for DR Beta/MsPI
DRbeta/MspI blots were received from four laboratories. In spite of the standardized technique, the overall intensity of the blots and the number of fragments detected were somewhat variable. Marker bands were...
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Chapter and Conference Paper
RFLP Standardization Report for DQ Beta/MspI
DQ beta/MspI blots were received from four laboratories and were analyzed as detailed in the report on DR beta/MspI. The DQ beta/MspI system identified 22 fragments on the core cell lines (Table 1 and Figs. 1 ...
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Chapter and Conference Paper
RFLP Standardization Report for DP Beta/MspI
DP beta/MspI blots were received from four laboratories and were analyzed as detailed in the report on DR Beta/MspI. The DP beta/MspI system identified 20 fragments on the core cell lines (Figs. 1 and 2). Nine...
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Chapter and Conference Paper
Myasthenia Gravis: Joint Report
Previous studies have demonstrated the importance of immunogenetic factors in myasthenia gravis (MG) (Table 1). In Caucasoids, generalized MG (GMG) is associated with A1,B8,DR3 (1,8,3). This particular supraty...
