7 Result(s)
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Chapter
Clinical Protocol Using New Neutron Irradiation Facility (JRR4) at JAERI
After the shutdown of the former JRR2, which had been used for boron neutron capture therapy (BNCT) in clinical cases, in summer 1998 a new neutron irradiation facility (JRR4) was installed as a medical reacto...
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Chapter
An Autopsy Report of a Glioblastoma Case after Boron Neutron Capture Therapy
Clinical trials of BNCT for glioblastoma have been underway around the World. In Japan, the new reactor JRR-4 has been now reconstructed especially for therapeutic irradiation. From the clinical point of view,...
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Chapter
In Vivo and In Vitro Uptake Study of Boronated Porphyrins for Neutron Capture Therapy
To improve boron neutron capture therapy (BNCT), a new tumor-seeking drug is required. Boronated porphyrins have been developed for boron carriers in boron neutron capture therapy (BNCT) with some positive res...
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Chapter
Apoptosis of Tumor Cells in Response to Boron Neutron Capture Therapy
We examined the incidence of radiation-induced apoptosis in 9L gliosarcoma cells in response to gamma-ray irradiation (single doses of 1, 10, or 20Gy), neutron irradiation, and BNCT using BSH or boronated meta...
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Chapter
Radiobiological Effects of Boronated Porphyrin (STA-BX909) Compared to BSH in Cultured Glioma Cell Line
Porphyrin is known as a tumor localizing agent that is clinically used in photo-dynamic therapy for cancers.1 Boronated porphyrins have also been developed2–7 and are now being investigated for possible clinical ...
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Chapter
Cell Cycle Change of 9L Glioma Cell after in Vitro Boron Neutron Capture Therapy
Proliferating tumor cell progress through the phases of each cell cycle. Cell cycle change such as G2/M arrest is known to occur in tumor cells after γ ray radiation.1,2 However, cell cycle change of tumor cell a...
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Chapter
The Advantage of Porphyrin for BNCT from the Point of View of Cell Cycle
The potential for using boronated porphyrins for BNCT have been reported by some groups.1–5 Our recent studies have also shown that porphyrin is one of the potential tumor targeting agents for BNCT.6,7 The tumor ...
