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Epidemiology of Cancer
Over 19 million new cancer cases lead to almost ten million deaths globally in 2020. The most common cancers worldwide are breast and lung cancers, while prostate cancer is the most common in the male populati...
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The Role of Epigenetics in Brain and Spinal Cord Tumors
Identification of distinct genetic profiles in has improved the classification and uncovered novel diagnostic, prognostic, and predictive molecular biomarkers for improved prediction of treatment response ...
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Leveraging Tissue Engineering for Skin Cancer Models
Bioengineered in vitro three-dimensional (3D) skin model has emerged as a promising tool for recapitulating different types of skin cancer and performing pre-clinical tests. However, a full-thickness 3D model ...
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Bone Sarcoma
While relatively rare, primary bone sarcomas are associated with high morbidity and mortality. A comprehensive history, examination, and imaging work-up should be performed in any suspected bone sarcoma. Percu...
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High-Risk Population Based on BC Risk Factors
Breast cancer (BC) is the second leading cause of female cancers worldwide in 2018, followed by lung cancer, and the fifth fatal cancer, followed by lung, colorectal, gastric, and liver cancers. The incidence ...
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Clinical and Practical Recommendations in the Use of Exercise, Physical Therapy, and Occupational Therapy for Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a highly prevalent, severe, and dose-limiting toxicity of several chemotherapy regimens for the treatment of multiple cancers including lung, breast, prosta...
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Care for Breast Cancer Survivors
The number of cancer survivors is increasing globally. More than 15.5 million Americans in 2016 and 1.3 million Koreans in 2013 were living with cancer history. This growing population is expected to increase ...
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Single Cell Genomics for Tumor Heterogeneity
Single cell genomics became a universal and powerful tool to study cellular diversity at genomic levels in normal and disease conditions. Cancer is a disease of genomic instability which instigates clonal evol...
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Systematic Review of Exercise for Prevention and Management of Chemotherapy-Induced Peripheral Neuropathy
Chemotherapy-induced peripheral neuropathy (CIPN) is a highly prevalent and dose-limiting toxicity of many widely used chemotherapy regimens for the treatment of common cancers including lung, breast, prostate...
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The Heterogeneity of Lipid Metabolism in Cancer
The study of cancer cell metabolism has traditionally focused on glycolysis and glutaminolysis. However, lipidomic technologies have matured considerably over the last decade and broadened our understanding of...
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Adiponectin in Gastrointestinal Malignancies
Obesity and its related metabolic deregulation have poor prognosis for several cancers, including gastric cancer (GC) and colorectal cancer (CRC). Adiponectin (also known as adipoQ, Acrp30, GBP-28, and apM1) s...
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Gastric Cancer and Its Remedy
Gastric cancer or stomach cancer is a very harmful disease in which malignant cells grow in the tissues of the stomach at an uncontrolled rate. It is one of the most prevalent malignant diseases with one of th...
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Natural Agents Mediated Regulation of microRNAs: Do We Need Skilled Archers to Hit the Bullseye
MicroRNAs (miRNAs) are short noncoding RNAs, which control gene expression by messenger RNA degradation or translational repression. MicroRNAs are also reportedly involved in regulation of carcinogenesis, angi...
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Plant Cell and Organ Culture as an Alternative for the Production of Anticancer Compounds
Plants are the reservoirs of various valuable secondary metabolites like camptothecin, podophyllotoxin, and ginseng saponins which are used as anticancer agents. Plant cell and organ cultures are competent to ...
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The Heterogeneity of Lipid Metabolism in Cancer
The study of cancer cell metabolism has traditionally focused on glycolysis and glutaminolysis. However, lipidomic technologies have matured considerably over the last decade and broadened our understanding of...
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Enrichment and Detection of Circulating Tumor Cells and Other Rare Cell Populations by Microfluidic Filtration
The current standard methods for isolating circulating tumor cells (CTCs) from blood involve EPCAM-based immunomagnetic approaches. A major disadvantage of these strategies is that CTCs with low EPCAM expressi...
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Role of STAT3 in Liver Cancer
Hepatocellular carcinoma (HCC) is a malignant cancer that shows heterogeneous etiology and the third leading of cancer-related deaths in the world. In spite of its severity, there is only one systemic chemothe...
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Circulating Free Tumor DNA (ctDNA): The Real-Time Liquid Biopsy
It is now well established that DNA is shed or secreted into the circulation in both normal and disease states. However, the ability to exploit this knowledge for use in clinical medicine has only recently bee...
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Role of Hypoxia-Inducible Factor (HIF) in Liver Cancer
Liver cancer is one of the major causes of cancer-related deaths in the United States, accounting for 4.5% of the total estimated cancer deaths in 2016 and standing as the second leading cause of cancer-relate...
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Osmolytes Offset the Urea’s Effect on Protein Structure and Function
High concentrations of urea are accumulated intracellularly in marine elasmobranchs and inner medullary region of mammalian kidney. It has been found that methylamine organic osmolytes are accumulated in conce...