271 Result(s)
within
English
Biomedicine
**hu Zhu
Chapter
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Chapter
Functions and Clinical Significance of Myocardial Cell-Derived Immunoglobulins
Immunoglobulins (Igs) have been widely accepted to be exclusively expressed by B cells. Nonetheless, this theory is challenged by mounting evidence which suggests that Igs can also be generated by non B cells ...
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Chapter
Immunotherapy for Gastrointestinal Malignancies
Gastrointestinal (GI) malignancies comprise esophageal, stomach, liver, biliary tract, pancreatic, small bowel, appendiceal, colorectal, and anal cancer. All of them originate from the GI tract; however, their...
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Enhancing Chemical Diversity of Fungal Secondary Metabolite by OSMAC Strategy
Fungal secondary metabolites (SMs) with therapeutic potential have played and continue to play an important role in new drug discovery. These substances are biosynthetically formed through a series of sequenti...
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Technologies Used for Analysis of Extracellular Vesicle-Omics
Extracellular vesicles (EVs) are naturally occurring and secreted membrane vesicles that carry proteins, lipids, and RNAs (mRNAs, microRNAs [miRNAs], and long noncoding RNAs [lncRNAs]) and play important roles...
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Chapter
The Gene Rearrangement and Transcriptional Regulation of Non B Cell-Derived Immunoglobulin
Traditionally, immunoglobulin (Ig) expression has been attributed solely to B cells/plasma cells with well-documented and accepted regulatory mechanisms governing Ig expression in B cells. Ig transcription is ...
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Neural Stem Cell Intervention in Traumatic Brain Injury
is a major cause of death and disability worldwide. The secondary brain damage post-TBI encompasses , metabolic changes, necrosis, excitotoxicity, and neuroinflammation. These processes further intensify the...
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Chapter
Aquaporins in Respiratory System
Aquaporins (AQPs) are water channel proteins facilitating fluid transport in alveolar space, airway humidification, pleural fluid absorption, and submucosal gland secretion. In this chapter, we mainly focus on...
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Chapter and Conference Paper
Critical Role of VEGF as a Direct Regulator of Photoreceptor Function
Vascular endothelial growth factor (VEGF or VEGF-A), a major pathogenic factor for diabetic and hypoxic blood–retina barrier (BRB) diseases, has been shown to act as a direct functional regulator for neurons i...
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Chapter
H2S Signals and Renin Angiotensin System in Cardiovascular Diseases
(H2S) is recently recognized as the third gasotransmitter alongside with nitric oxide and carbon monoxide. H2S exerts multifaceted physiological functions, including antioxidant, anti-inflammation, anti-apoptosi...
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iPSCs-Derived Neurons and Brain Organoids from Patients
Induced pluripotent stem cells (iPSCs) can be differentiated into specific neurons and brain organoids by adding induction factors and small molecules in vitro, which carry human genetic information and recapi...
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Chapter
Clinical Manifestations of Hepatitis E
The clinical manifestations of hepatitis E are similar to those of other types of viral hepatitis. While acute hepatitis E is usually self-limited, pregnant women and chronic liver disease patients suffering f...
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Chapter
iPSCs-Based Therapy for Trabecular Meshwork
The trabecular meshwork (TM) of the eye serves as an essential tissue in controlling aqueous humor (AH) outflow and intraocular pressure (IOP) homeostasis. However, dysfunctional TM cells and/or decreased TM c...
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Myocardial Tissue Repair and Regeneration
Heart failure caused by myocardial infarction (MI) remains a major threat to human health. After MI, a series of pathological events take place, including apoptosis of cardiac cells, arrhythmia, inflammation, ...
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Chapter
New Approaches Targeting Immuno-oncology and Tumor Microenvironment
Immune checkpoint blockade therapy is now a key tool in the war against cancer. Antibody medications, such as anti-PD-1 and anti-PD-L1, have several clear benefits, including broad applicability across cancer ...
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Chapter
Pseudotyped Viruses for Orthohantavirus
Orthohantaviruses, members of the Orthohantavirus genus of Hantaviridae family of the Bunyavirales order, are enveloped, negative-sense, single-stranded, tripartite RNA viruses. They are emerging zoonotic pathoge...
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Extracellular Vesicles and Ischemic Cardiovascular Diseases
Characterized by coronary artery obstruction or stenosis, ischemic cardiovascular diseases as advanced stages of coronary heart diseases commonly lead to left ventricular aneurysm, ventricular septal defect, a...
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Chapter
Synbiotics: Promising Approach for the Therapeutic Management of Cancer
Cancer represents a wide range of diseases that could begin in any parts of the body when cells grow abnormally and uncontrollably exceeding their normal boundaries. Cancer is a major health concern as statist...
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Chapter
NAADP-Dependent TPC Current
Two-pore channels, TPC1 and TPC2, are Ca2+- and Na+-permeable cation channels expressed on the membranes of endosomes and lysosomes in nearly all mammalian cells. These channels have been implicated in Ca2+ signa...
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Chapter
Hypothalamic-Pituitary-Adrenal Axis: A Bridge Between Acupuncture and Diseases
Acupuncture has been widely used for pain and stress-related diseases management in clinics, but the underlying mechanism still needs to be clarified. Hypothalamic-pituitary-adrenal (HPA) axis plays an essenti...
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Chapter and Conference Paper
RDNet: ResNet-18 with Dropout for Blood Cell Classification
(Aims) Blood cells are hematopoietic pluripotent stem cells derived from bone marrow. Blood diseases occur primarily in the hematopoietic system and can affect the hematopoietic system with abnormal blood changes...
