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Chapter
The Crystal Structure of Mitochondrial Cytochrome bc 1 Complex
The cytochrome bc 1 complex (commonly known as ubiquinol-cytochrome c reductase, or complex III) is a segment of the mitochondrial respiratory chain that catalyzes antimycin-sensitive electron transfe...
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Chapter
Iron in mammals: pathophysiological mechanisms of overload and deficiency in relation to disease
The uptake of iron into the body is tightly regulated in humans and in other mammals. Mutations in key proteins that transport, sense, metabolize, and facilitate the utilization of iron cause perturbations in ...
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Chapter
Reconstruction and Structural Analysis of Metabolic and Regulatory Networks
Networks of interacting cellular components carry out the essential functions in living cells. Therefore, understanding the evolution and design principles of such complex networks is a central issue of system...
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Chapter
Fidelity Mechanisms of the Aminoacyl-tRNA Synthetases
The central dogma and its accurate interpretation by a large array of biomolecules remains a fascinating process. Understanding its mechanisms of decoding holds tremendous potential for the future of protein e...
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Chapter
Modeling of Intracellular Transport and Compartmentation
The complexity and internal organization of mammalian cells as well as the regulation of intracellular transport processes has increasingly moved into the focus of investigation during the past two decades. Ad...
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Chapter
Role of DJ-1 in Fertilization
Neither a sperm nor an egg can develop into an individual alone. Only when the sperm and egg bind and fuse, which is known as fertilization, can they acquire the ability of develo** into new individuals. DJ-...
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Chapter
Targeting Bone Marrow-Derived Fibroblasts for Renal Fibrosis
Renal fibrosis is a major pathological feature of chronic kidney disease, which is characterized by massive fibroblast activation and excessive production and deposition of extracellular matrix (ECM). Renal fi...