72 Result(s)
within
Chapter
**** Chu
Biomedicine
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Chapter
Über die Bedeutung der Schilddrüse für die stoffwechselsteigernde Wirkung von Amphetamin
The rate of oxygen consumption and carbon dioxide production was measured in rats following the injection of amphetamine. Amphetamine is strongly calorigenic in normal as well as in triiodothyronine treated th...
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Induction and Analysis of Gene Mutations in Mammalian Cells in Culture
For more than 30 years it has been known that human and other mammalian cells can grow in vitro as microorganisms. Although the potential of using these cell cultures for genetic studies has long been recognized,...
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Selective Systems in Somatic Cell Genetics
Experimental mutagenesis, cell hybridization, and intercellular gene transfer appear to be the three most significant technical developments in recent years that have stimulated rapid advances in somatic cell ...
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Chapter and Conference Paper
Chemoreflexive Ventilatory Response at Sea Level in Subjects With Past History of Good Acclimatization and Severe Acute Mountain Sickness
It is well established that an initial hyperpneic response is of great importance in the early acclimatization to high altitude, in which the peripheral chemoreceptors play a prominent role. It would be intere...
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Chapter and Conference Paper
Comparative Toxicity and Metabolism of Tetrachlorobenzene Isomers
LD50 values for 1,2,3,4-, 1,2,4,5- and 1,2,3,5-tetrachloro- benzene (TCB) were found to be 1470, 3105 and 2297 mg·kg-1, respectively, in male rats. In females the LD50 values were found to be 1167 and 1727 mg·kg-...
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Candidemia in Patients with Acquired Immunodeficiency Syndrome
Positive blood cultures for Candida species from January 1981 to November 1989 were reviewed at Memorial Sloan-Kettering Cancer Center. Thirteen patients with AIDS were found to have candidemia. The most common s...
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The Molecular Epidemiology of Dengue Viruses
Dengue (DEN) fever is a mosquito-transmitted flavivirus disease of humans which has affected untold millions of people over the world during the past two centuries (reviewed by Schlesinger, 1979; Gubler, 1988)...
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Chapter and Conference Paper
Geographical distribution of hemorrhagic fever with renal syndrome and hantaviruses
World-wide, about 150,000 people are hospitalized with hemorrhagic fever with renal syndrome (HFRS) (3–10% fatality) each year. The etiologic agents of HFRS are Hantaan, Seoul, and Puumala viruses of the genus Ha...
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Growth Factor Signal Transduction in Human Intestinal Cells
One of the basic biological problems in the area of developmental gastroenterology is to understand the factors and mechanisms controlling the intestinal epithelial cell growth and differentiation. Enterocytes...
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Acute Alterations in Phosphoinositide Turnover
In the develo** nervous system, selected excitatory amino acid (EAA) recognition sites are coupled to activation of phospholipase C, the enzyme that catalyzes the hydrolysis of membrane inositol phospholipid...
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Bovine Collagen Modified by PEG
Currently much interest has been shown in attaching poly(ethylene glycol) (PEG) to proteins as a means of increasing solubility and serum lifetime.1–3 Modification of proteins by PEG has been used to reduce the i...
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Chapter and Conference Paper
Resistance of SOD-Transgenic Mice to Oxidative Stress
The activity of CuZn-superoxide dismutase (CuZnSOD) in the brain and other tissues of mice has been increased between 1.5- and 5-fold by the insertion of one or more human CuZnSOD transgenes into the mouse gen...
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New Insights into the Role of Oxygen Radicals in Cerebral Ischemia
uring the past few decades, a large body of experimental data has accumulated indicating that the biological reduction of molecular oxygen could yield dangerously reactive free radical intermediates (Fridovich...
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Effects of Endogenous Nitric Oxide on Basal Vasomotor Tone and Stimulated Endothelium-Dependent Responses in the Coronary Arterial Circulation
This study assesses the role of nitric oxide in basal vasomotor tone and stimulated endothelium-dependent dilations in the coronary arteries of chronically-instrumented awake dogs by examining the responses to...
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Crystal Structures and Molecular Conformations of Anti-HIV Nucleosides
Since the discovery of 3′-azido-3′-deoxythymidine (AZT) as the first drug for the treatment of AIDS, considerable efforts have been made to develop new nucleoside analogues that would be more active, less toxi...
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Stereocontrolled Routes for the Synthesis of Anti-HIV and Anti-HBV Nucleosides
The discovery of the clinical usefulness of 2′-deoxy- and 2′,3′-dideoxy nucleoside analogues for the treatment of viral infections such as acquired immunodeficiency syndrome, hepatitis B virus, cytomegalovirus...
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Protection of Cats from Infectious Peritonitis by Vaccination with a Recombinant Raccoon Poxvirus Expressing the Nucleocapsid Gene of Feline Infectious Peritonitis Virus
Feline Infectious Peritonitis Virus (FIPV) is a coronavirus that induces an often fatal, systemic infection in cats. Various vaccines designed to prevent FIPV infection have been shown to exacerbate the diseas...
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Efficacy of an Inactivated Vaccine against Clinical Disease Caused by Canine Coronavirus
Canine Coronavirus (CCV) is a causative agent of diarrhea in dogs. The reproduction of severe clinical disease with experimental CCV infection has been difficult. We have recently developed a CCV challenge mod...
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Role of the Ku Autoantigen in V(D)J Recombination and Double-Strand Break Repair
All cells have biochemical pathways for repairing DNA double-strand breaks induced by ionizing radiation (X-rays) and oxidative metabolism. Lymphoid cells also have a V(D)J recombination pathway for rearrangin...
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Methods for Evaluating in Vivo Rodent Models for Alzheimer’s Disease
In general, aged rodents do not show classical Alzheimer’s disease (AD) pathology. Although aged rats do not normally contain ß-amyloid protein (Aß)-rich plaques nor neurofibrillary tangles (NFT), in rare inst...
