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Production and Formulation of Adenovirus Vectors
Adenovirus vectors have attracted considerable interest over the past decade, with ongoing clinical development programs for applications ranging...
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Nonviral Delivery of Cancer Genetic Vaccines
The potential use of genetic vaccines to address numerous diseases including cancer is promising, but currently unrealized. Here, we review...
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Advanced Targeting Strategies for Murine Retroviral and Adeno-associated Viral Vectors
Targeted gene delivery involves broadening viral tropism to infect previously nonpermissive cells, replacing viral tropism to infect a target cell...
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Molecular Conjugates
Molecular conjugates are nanometer-sized entities consisting of synthetic materials (lipids, polycations, targeting agents, and so on) and nucleic...
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Lentiviral Vectors
We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with...
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Plasmid Vaccines and Therapeutics: From Design to Applications
In the late 1980s, Vical and collaborators discovered that the injection into tissues of unformulated plasmid encoding various proteins resulted in...
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Adeno-associated Virus as a Gene Therapy Vector: Vector Development, Production and Clinical Applications
Adeno-associated virus (AAV) has emerged as an attractive vector for gene therapy. AAV vectors have successfully been utilized to promote...
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Effects of Sex Steroids on Innate and Adaptive Immunity
Estrogens and androgens are classically recognized as reproductive sex steroid hormones because of their well-documented effects on reproductive...
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Bechterew’s Syndrome
Bechterew’s syndrome was used to explain the classic and old manifestation of ankylosing spondylitis (AS) and spondyloarthropathy (SpA) and also is...
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Fraser Syndrome (FRASRS)
Fraser syndrome, reported by George Fraser in 1962, is a rare autosomal recessive genetic disorder with three subdivisions (type 1, 2, and 3) (Fraser...
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49, XXXYY Syndrome
49, XXXYY syndrome, also known as XXXYY syndrome, is a chromosomal disorder first reported in 1963 (Benn et al. 1982). Key diagnostic features of...
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Split-Hand/Foot Malformation (SHFM)
Split-hand/foot malformation (SHFM) is a congenital limb defect affecting the central rays of the autopod that consists of hypoplasia of digits...
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Ascher Syndrome
Blepharochalasis and double Lip, Laffer-Ascher
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Autoimmune Polyendocrine Syndrome Type 2 (APS2)
Polyglandular autoimmune syndrome type 2 (APS-2) is an autoimmune disorder inherited through multiple genes. It is also referred to as Carpenter...
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Albinism-Deafness Syndrome (ADFN)
OMIM: #300700
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Trehalase Deficiency
Trehalose is a nonreducing disaccharide extracted from insect larvae called “trehala manna” by Berthelot in 1858 and named trehalose. Trehalose is...
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Iridogoniodysgenesis (IGD) and Skeletal Anomalies
Not available.
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Sudden Unexpected Death in Epilepsy (SUDEP)
Sudden unexpected death in epilepsy (SUDEP) is a common cause of premature mortality among people with epilepsy (PWE). The overall incidence rate of...
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The Role of Ion Channel in Epilepsy Including SUDEP Cases
Epilepsy is a central nervous system disorder characterized by recurrent seizures. Identification of seizures with excessive electrical activity can...