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Advanced Targeting Strategies for Murine Retroviral and Adeno-associated Viral Vectors
Targeted gene delivery involves broadening viral tropism to infect previously nonpermissive cells, replacing viral tropism to infect a target cell...
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Nonviral Delivery of Cancer Genetic Vaccines
The potential use of genetic vaccines to address numerous diseases including cancer is promising, but currently unrealized. Here, we review...
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Production and Formulation of Adenovirus Vectors
Adenovirus vectors have attracted considerable interest over the past decade, with ongoing clinical development programs for applications ranging...
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Molecular Conjugates
Molecular conjugates are nanometer-sized entities consisting of synthetic materials (lipids, polycations, targeting agents, and so on) and nucleic...
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Lentiviral Vectors
We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with...
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Plasmid Vaccines and Therapeutics: From Design to Applications
In the late 1980s, Vical and collaborators discovered that the injection into tissues of unformulated plasmid encoding various proteins resulted in...
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Adeno-associated Virus as a Gene Therapy Vector: Vector Development, Production and Clinical Applications
Adeno-associated virus (AAV) has emerged as an attractive vector for gene therapy. AAV vectors have successfully been utilized to promote...
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Effects of Sex Steroids on Innate and Adaptive Immunity
Estrogens and androgens are classically recognized as reproductive sex steroid hormones because of their well-documented effects on reproductive...
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Post-traumatic Epilepsy and Neuropsychiatric Comorbidities
Post-traumatic epilepsy (PTE) is a form of acquired epilepsy that arises from traumatic brain injury (TBI). It presents a complex relationship with...
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The Genetics of Cerebral Microbleeds
Cerebral microbleeds are a radiological marker of small areas of haemorrhage in the brain, seen on magnetic resonance imaging sequences sensitive to...
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Intracerebral Hemorrhage and Cerebral Amyloid Angiopathy
Intracerebral hemorrhage (ICH) is the acute manifestation of chronic cerebral small vessel disease. ICH is classified according to the affected brain...
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Genetics of Small Vessel Disease
Cerebral small vessel disease (CSVD) is highly prevalent in the general population and is overall a leading cause of disability. CSVD manifestations...
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Diagnosis, Investigation, Treatment and Management of Young Stroke in Clinic
It has been estimated that approximately 10% of all strokes occur in young adults. Stroke in young people has a significant long-term socioeconomic...
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Multi-Omics Approaches to Discovering Acute Stroke Injury and Recovery Mechanisms
Millions of people suffer an acute stroke each year, resulting in an enormous global burden of residual disability and mortality. Despite decades of...
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Identification of Host Factors of Paramyxoviruses by siRNA Genome-Wide Screens
Measles is a highly infectious disease that continues to spread mainly in develo** countries, often resulting in child mortality. Despite the...
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Culturing Immortalized Human Airway Epithelial Cells at an Air-Liquid Interface for Measles Virus Infection
Measles virus (MeV) infection of airway surface epithelial cells provides a site for final amplification before being released back into the...
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Proximity Ligation Assay to Detect the Proximity Between Host Proteins and Viral Proteins of HIV-1
The study of host-pathogen interaction often requires interrogating the protein-protein interactions and examining post-translational modifications...
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Molecular Analysis of Copy-Back Defective Interfering RNAs of Morbilliviruses
Copy-back defective interfering RNAs are major contaminants of viral stock preparations of morbilliviruses and other negative strand RNA viruses....