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Effects of Sex Steroids on Innate and Adaptive Immunity
Estrogens and androgens are classically recognized as reproductive sex steroid hormones because of their well-documented effects on reproductive...
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Post-traumatic Epilepsy and Neuropsychiatric Comorbidities
Post-traumatic epilepsy (PTE) is a form of acquired epilepsy that arises from traumatic brain injury (TBI). It presents a complex relationship with...
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Macrolides and Asthma Therapy
Asthma is a chronic condition of the airways that is typified by bronchial hyperresponsiveness, variable airflow obstruction, and airway...
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Macrolides in Chronic Skin Disorders
Macrolide antibiotics are widely used to treat infections of soft tissues and the respiratory tract due to their efficacy against Gram-negative and...
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Macrolides and Diseases Associated with Loss of Epithelial Barrier Integrity
In addition to the antiinflammatory/immunoregulatory actions of macrolide antibiotics, more recent investigations indicate the potential...
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Azithromycin for Other Lung Diseases: Lung Transplantation and Sarcoidosis
Azithromycin was introduced in lung transplantation in an attempt to improve the pulmonary function in patients with chronic allograft dysfunction...
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Macrolides and Cystic Fibrosis
Macrolide antibiotics attracted interest as a potential therapy in cystic fibrosis (CF) due to remarkable similarities in pathogenic features with...
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Non-CF Bronchiectasis
Bronchiectasis is a disease of recurrent wet cough and acute respiratory exacerbations with objective confirmation by abnormal bronchial dilatation...
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The Role of Ion Channel in Epilepsy Including SUDEP Cases
Epilepsy is a central nervous system disorder characterized by recurrent seizures. Identification of seizures with excessive electrical activity can...
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Synergistic Combination Immunotherapy of Glioblastoma
Glioblastoma, a highly aggressive and malignant brain tumor classified as WHO grade IV, continues to pose a significant challenge despite the current...
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Immunotherapy of Solid Tumors Based on Neoantigen Vaccines
The term “cancer immunotherapy” refers to a broad spectrum of therapeutic modalities that use the immune system to trigger specific anticancer immune...
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The Role of HPV in Head and Neck Cancer
Human papillomavirus (HPV) infection is sexually transmitted, and it is widely spread in the head and neck region, but its role in tumor development...
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Emerging Roles of Sodium/Calcium Exchangers in Cancer
Cancer is a group of neoplastic diseases that shares as common feature uncontrolled cellular proliferation. Tumorigenesis and cancer progression are...
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B Cells and Antibody Production in Cancer
B cells and their products play a key role in the development and progression of cancers, with pro- and antitumoral functions in the tumor...
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Potential of Patient-Derived Organoids and Other 3D Culture Models to Assess Immunotherapy Response in Cancer
Immunotherapy has arisen as a promising approach for treating cancer, but its use in the clinical field is still mostly limited to advanced patients....
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Sudden Unexpected Death in Epilepsy (SUDEP)
Sudden unexpected death in epilepsy (SUDEP) is a common cause of premature mortality among people with epilepsy (PWE). The overall incidence rate of...
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TCR Signals Controlling Adaptive Immunity against Toxoplasma and Cancer
T cells play a crucial role in adaptive immunity by recognizing and eliminating foreign pathogens and abnormal cells such as cancer cells. T cell...
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Novel Insights into the Autoimmunity from the Genetic Approach of the Human Disease
Autoimmune-polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a monogenic inborn error of autoimmunity that is caused by damaging...
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Development of Orally Ingestible IgA Antibody Drugs to Maintain Symbiosis Between Humans and Microorganisms
In recent years, dysbiosis, abnormalities in the gut microbiota, has been reported to be associated with the development of many diseases, and...
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Autoinflammatory Diseases Due to Defects in Degradation or Transport of Intracellular Proteins
The number of human inborn errors of immunity has now gone beyond 430. The responsible gene variants themselves are apparently the cause for the...