30 Result(s)

Chapter and Conference Paper

Myelination in the Mouse by Transplanted Oligodendrocytes

Numerous observations especially in man in case of multiple sclerosis or after spinal cord trauma, have shown that at adult stage, demyelinated sites can be at least partially spontaneously repaired by Schwann...

M. Gumpel, F. Lachapelle, M. Baulac… in Glial-Neuronal Communication in Developmen… (1987)

Chapter and Conference Paper

Characterization and Expression of the Glycoprotein Receptor for Murine Coronavirus

Coronaviruses are a family of large, enveloped, viruses with helical nucleocapsids and a single stranded genomic RNA of approximately 30kb of message sense (Sturman and Holmes, 1983; Spaan et al., 1988). These vi...

Kathryn V. Holmes, Richard K. Williams in Microbial Adhesion and Invasion (1992)

Chapter and Conference Paper

Does the Pulmonary Surfactant System Yield Meaningful Parameters in Inhalation Toxicity Studies? A Review

The existence of a surface active agent (surfactant) in the lung was first postulated by von Neergard in 1929. He himself did not seem to recognize the importance of his discovery, and it was up to other inves...

R. Klingebiel, U. Heinrich in Advances in Controlled Clinical Inhalation Studies (1993)

Chapter and Conference Paper

Metabolic Reactions and Recombinant Isoenzymes of Cytochrome P450: Information Generated and Value for Pharmaceutical Development

Cytochrome P450s are heme-containing mono-oxygenases which encompass a multi-isoenzyme superfamily whose chemical hydroxylation specificity includes xenobiotics as important as pharmaceuticals and carcinogens ...

R. E. Tynes in Assessment of the Use of Single Cytochrome P450 Enzymes in Drug Research (1994)

Chapter and Conference Paper

Basic mechanisms of brain inflammation

The mechanisms, how the immune system surveys the nervous tissue and how brain inflammation is regulated are essential questions for therapy of neuroimmunological diseases. The nervous system is continuously p...

Prof. Dr. H. Lassmann in Advances in Research on Neurodegeneration (1997)

Chapter and Conference Paper

Vitamin C in Respiratory Diseases

Free radicals (such as RS^•, RSO₂ ^•, SO₃ ^-•, NO^•, NO₂ ^•, LO^•, LOO^•, CCl₃ ^•) and other reactive oxygen species (ROS) (O₂ ^-• , H

P. C. Braga in Vitamin C (1998)

Chapter and Conference Paper

Myelin dysfunction/degradation in the central nervous system: why are myelin sheaths susceptible to damage?

In the central nervous system, myelin sheaths are produced to electrically insulate axons and to increase the velocity of axonal conduction. They are highly complex structures, which are often destructed in ne...

Dr. Monika Bradl in Advances in Research on Neurodegeneration (1999)

Chapter and Conference Paper

Mechanisms of tissue injury in multiple sclerosis: opportunities for neuroprotective therapy

Development of neuroprotective therapies for multiple sclerosis is dependent on defining the precise mechanisms whereby immune effector cells and molecules are able to induce relatively selective injury of oli...

S. Pouly, J. P. Antel, U. Ladiwala… in Advances in Research on Neurodegeneration (2000)

Chapter and Conference Paper

The Pederin Family of Antitumor Agents: Structures, Synthesis and Biological Activity

In 1775 the Danish entomologist Johann Christian Fabricius (1745-1808) first described the genus Paederus, which at that time included only two species. In the ensuing two centuries, over 600 species have been id...

R. Narquizian, P. J. Kocienski in The Role of Natural Products in Drug Discovery (2000)

Chapter and Conference Paper

Target Discovery and Validation

The pharmaceutical industry as we know it is still relatively young and only started to emerge about 100 years ago, as advances in chemistry and biology made the discovery and synthesis of drugs possible. In t...

R. Solari in From Morphological Imaging to Molecular Targeting (2004)

Chapter and Conference Paper

New Therapeutics Targets in Chronic Viral Cardiomyopathy

Dilated cardiomyopathy (DCM) is a prevalent heart muscle disease characterized by impaired contractility and dilation of the ventricles. Recent clinical research suggests that cardiotropic viruses are importan...

W. Poller, H. Fechner, U. Kühl… in Chronic Viral and Inflammatory Cardiomyopa… (2006)

Chapter and Conference Paper

Erratum

Taurine 7 (2009)

Chapter and Conference Paper

Counteraction to CBRN Terrorism in Switzerland

In Switzerland, the planning of security policy measures now increasingly factors in scenarios involving the use of CBRN weapons on Swiss soil. While there have been no terrorist “spectaculars” or dramatic new...

M. Kenzelmann, D. Storch in Counteraction to Chemical and Biological T… (2009)

Chapter and Conference Paper

Strategies of Preparedness Response to Biological Warfare and Bioterrorism Threats

Risks associated with deliberate use of biological agents against population and the needs for a strong public health system are well recognized. The potential use of biological agents is mounting every day, e...

F. Paul in Counteraction to Chemical and Biological Terrorism in East European Countries (2009)

Chapter and Conference Paper

Infections Diseases in the Context of Terrorist Threat

From the great number of pathogenic and conventionally pathogenic for human beings microorganisms, only some of them can be used for terroristic purposes, since they should meet a lot of the relevant propertie...

M. Andreychyn, V. Kopcha in Counteraction to Chemical and Biological T… (2009)

Chapter and Conference Paper

The Use of Adverse Outcome Pathways (AOPs) to Support Chemical Safety Decisions Within the Context of Integrated Approaches to Testing and Assessment (IATA)

New streamlined approaches that use fewer resources and animals are needed for the safety assessment of chemicals. Data gathering should be streamlined to fit regulatory need and the specific properties of the...

Catherine Willett in Alternatives to Animal Testing (2019)

Chapter and Conference Paper

Alternative Methods for Developmental Toxicity Testing Using Mouse ESCs

Development of an organism is accompanied by rapid and complex changes within a relatively short period, and embryotoxic chemicals administered to a mother during pregnancy can result in persistent lesions, ge...

Hee Young Kang, Eui-Bae Jeung in Alternatives to Animal Testing (2019)

Chapter and Conference Paper

The Lush Prize and Young Researcher Asia Awards 2016

The Lush Prize is now in its fifth year and awards a total of 52,000,000 JPY (approx.) annually to initiatives working to end the use of animals in toxicology testing. There are six categories of award: Scienc...

Rebecca Ram in Alternatives to Animal Testing (2019)

Chapter and Conference Paper

Testing Method Development and Validation for in Vitro Skin Irritation Testing (SIT) by Using Reconstructed Human Epidermis (RhE) Skin Equivalent - EPiTRI^®

Current regulatory requirements focus on assessment of acute irritation potential of chemicals and cosmetics in order to support risk management. A trend has been changed from in vivo to in vitro testing due to 3...

Yu-Chun Lin, Hui-Chun Hsu, Chiu-Hsing Lin, Cheng-Yi Wu… in Alternatives to Animal Testing (2019)

Chapter and Conference Paper

Alternative Research (3Rs) in the World, Asia and Japan

Alternative research is currently conducted all over the world and its recent progress is remarkable as 3Rs research. This article describes a review of alternative research and 3Rs in the world, Asia and Japan.

Tsutomu Miki Kurosawa in Alternatives to Animal Testing (2019)