20 Result(s)
within
English
Biochemistry, general
Pharmacology/Toxicology
Yi** **
Chapter
Conference Paper
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Chapter and Conference Paper
Metabolic Reactions and Recombinant Isoenzymes of Cytochrome P450: Information Generated and Value for Pharmaceutical Development
Cytochrome P450s are heme-containing mono-oxygenases which encompass a multi-isoenzyme superfamily whose chemical hydroxylation specificity includes xenobiotics as important as pharmaceuticals and carcinogens ...
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Chapter and Conference Paper
Myelin dysfunction/degradation in the central nervous system: why are myelin sheaths susceptible to damage?
In the central nervous system, myelin sheaths are produced to electrically insulate axons and to increase the velocity of axonal conduction. They are highly complex structures, which are often destructed in ne...
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Chapter and Conference Paper
Mechanisms of tissue injury in multiple sclerosis: opportunities for neuroprotective therapy
Development of neuroprotective therapies for multiple sclerosis is dependent on defining the precise mechanisms whereby immune effector cells and molecules are able to induce relatively selective injury of oli...
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Chapter and Conference Paper
The Pederin Family of Antitumor Agents: Structures, Synthesis and Biological Activity
In 1775 the Danish entomologist Johann Christian Fabricius (1745-1808) first described the genus Paederus, which at that time included only two species. In the ensuing two centuries, over 600 species have been id...
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Chapter and Conference Paper
Erratum
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Chapter and Conference Paper
The Use of Adverse Outcome Pathways (AOPs) to Support Chemical Safety Decisions Within the Context of Integrated Approaches to Testing and Assessment (IATA)
New streamlined approaches that use fewer resources and animals are needed for the safety assessment of chemicals. Data gathering should be streamlined to fit regulatory need and the specific properties of the...
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Chapter and Conference Paper
Alternative Methods for Developmental Toxicity Testing Using Mouse ESCs
Development of an organism is accompanied by rapid and complex changes within a relatively short period, and embryotoxic chemicals administered to a mother during pregnancy can result in persistent lesions, ge...
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Chapter and Conference Paper
The Lush Prize and Young Researcher Asia Awards 2016
The Lush Prize is now in its fifth year and awards a total of 52,000,000 JPY (approx.) annually to initiatives working to end the use of animals in toxicology testing. There are six categories of award: Scienc...
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Chapter and Conference Paper
Testing Method Development and Validation for in Vitro Skin Irritation Testing (SIT) by Using Reconstructed Human Epidermis (RhE) Skin Equivalent - EPiTRI®
Current regulatory requirements focus on assessment of acute irritation potential of chemicals and cosmetics in order to support risk management. A trend has been changed from in vivo to in vitro testing due to 3...
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Chapter and Conference Paper
Alternative Research (3Rs) in the World, Asia and Japan
Alternative research is currently conducted all over the world and its recent progress is remarkable as 3Rs research. This article describes a review of alternative research and 3Rs in the world, Asia and Japan.
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Chapter and Conference Paper
Progress in Eliminating One-Year Dog Studies for the Safety Assessment of Pesticides
We reviewed six key peer-reviewed publications that assessed the need for one-year studies of pesticide toxicity in dogs. Each of the six papers took a different approach to comparing the value of one-year stu...
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Chapter and Conference Paper
Guidance on the Use of Alternative Test Methods for the Safety Assessment of Cosmetics and Quasi-drugs
In accordance with a notification issued by Japan’s Ministry of Health, Labour and Welfare (MHLW) in 2011, the Japanese Center for the Validation of Alternative Methods (JaCVAM) has accelerated applications fo...
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Chapter and Conference Paper
3Rs in Quality Control of Human Vaccines: Opportunities and Barriers
The 3Rs principles – Replacement, Reduction, Refinement – were established in 1959 and since then have been adopted widely and particularly in Europe with the European Directive 2010/63/EU. The vaccine industr...
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Chapter and Conference Paper
Mechanism-Based Evaluation System for Hepato- and Nephrotoxicity or Carcinogenicity Using Omics Technology
We have been develo** a carcinogenicity prediction system based on gene expression profiles focusing on omics technology to enable mechanism-based evaluations of toxicity to reduce the numbers of animals and...
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Chapter and Conference Paper
Zebrafish, Danio Rerio as a Replacement Alternative Model Useful in CKDu Experiments
Zebrafish (Danio rerio) and its embryo has become a popular replacement alternative among the scientists because of many scientific attributes. As it is a model commonly used in ecotoxicology, our plan is to use ...
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Chapter and Conference Paper
Development the Technique for the Preparation and Characterization of Reconstructed Human Epidermis (RHE)
Reconstructed Human Epidermis (RHE) is an artificial epidermis made in such a way that it resembles human skin, and can be used for the identification of irritant chemicals, especially for cosmetic and topical...
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Chapter and Conference Paper
Approaches to Reducing Animal Use for Acute Toxicity Testing: Retrospective Analyses of Pesticide Data
In this study, we considered whether acute oral toxicity hazard classifications for pesticide formulations and active ingredients (AIs) could be used to assign acute dermal toxicity hazard classifications usin...
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Chapter and Conference Paper
Cosmetic Regulation and Alternatives to Animal Experimentation in India
United Kingdom was the first to ban animal testing of cosmetics, and it happened in 1998. The European Union (EU) went through legislations and endeavors implementing animal testing ban in a phased manner, and...
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Chapter and Conference Paper
Alternatives and Refinement for Animal Experimentation in Cancer Research
Globally cancer is a major public health issue and is a second biggest cause of deaths. Although animal models have limitations in terms of predictive and translational value to humans, they have played a majo...
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Chapter and Conference Paper
Futuristic Approach to Alternative Model Organisms: Hydra Stakes Its Claim
The use of mammalian models for toxicological risk assessment of chemicals has been a widespread practice for well over 50 years. This has remained controversial in view of the species differences. Further, th...
