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Chapter and Conference Paper
Mafosfamide — A Derivative of 4-Hydroxycyclophosphamide
The chemical development of mafosfamide (MA)-L-lysine salt as a “stabilized” prodrug of 4-hydroxyCP, i.e. the solid-state unstable primary metabolite of the anticancer drug cyclophosphamide (CP), involved a st...
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Chapter and Conference Paper
Calcitonins — Physiological and Pharmacological Aspects
Calcitonin is an endogenous regulator of calcium homeostasis, acting principally on bone. The hormone has been isolated from several species of vertebrate, and four types are currently in therapeutic use. Thos...
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Chapter and Conference Paper
Enzymatic DNA Methylation
The genome of mammals contains in addition to the four major DNA bases small amounts of 5-methylcytosine. The functional role of this DNA base has been the subject of numerous investigations especially during ...