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    Chapter and Conference Paper

    Machine Learning and Ethics

    When new technology is introduced into healthcare, novel ethical dilemmas arise in the human-machine interface. As artificial intelligence (AI), machine learning (ML) and big data can exhaust human oversight a...

    Tiit Mathiesen, Marike Broekman in Machine Learning in Clinical Neuroscience (2022)

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    Chapter and Conference Paper

    Natural Language Processing Applications in the Clinical Neurosciences: A Machine Learning Augmented Systematic Review

    Natural language processing (NLP), a domain of artificial intelligence (AI) that models human language, has been used in medicine to automate diagnostics, detect adverse events, support decision making and pre...

    Quinlan D. Buchlak, Nazanin Esmaili in Machine Learning in Clinical Neuroscience (2022)

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    Chapter and Conference Paper

    At the Pulse of Time: Machine Vision in Retinal Videos

    Spontaneous venous pulsations (SVP) are a common finding in healthy people. The absence of SVP is associated with rapid progression in glaucoma and increased intracranial pressure. Traditionally, SVP has been ...

    Timothy Hamann, Maximilian Wiest in Machine Learning in Clinical Neuroscience (2022)

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    Chapter and Conference Paper

    Machine Learning and Intracranial Aneurysms: From Detection to Outcome Prediction

    Machine learning (ML) is a rapidly rising research tool in biomedical sciences whose applications include segmentation, classification, disease detection, and outcome prediction. With respect to traditional st...

    Vittorio Stumpo, Victor E. Staartjes in Machine Learning in Clinical Neuroscience (2022)

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    Chapter and Conference Paper

    Machine Intelligence in Clinical Neuroscience: Taming the Unchained Prometheus

    The democratization of machine learning (ML) through availability of open-source learning libraries, the availability of datasets in the “big data” era, increasing computing power even on mobile devices, and o...

    Victor E. Staartjes, Luca Regli, Carlo Serra in Machine Learning in Clinical Neuroscience (2022)

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    Chapter and Conference Paper

    Radiomic Features Associated with Extent of Resection in Glioma Surgery

    Radiomics defines a set of techniques for extraction and quantification of digital medical data in an automated and reproducible way. Its goal is to detect features potentially related to a clinical task, like...

    Giovanni Muscas, Simone Orlandini in Machine Learning in Clinical Neuroscience (2022)

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    Chapter and Conference Paper

    Foundations of Machine Learning-Based Clinical Prediction Modeling: Part II—Generalization and Overfitting

    We review the concept of overfitting, which is a well-known concern within the machine learning community, but less established in the clinical community. Overfitted models may lead to inadequate conclusions that...

    Julius M. Kernbach, Victor E. Staartjes in Machine Learning in Clinical Neuroscience (2022)

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    Chapter and Conference Paper

    Introduction to Deep Learning in Clinical Neuroscience

    The use of deep learning (DL) is rapidly increasing in clinical neuroscience. The term denotes models with multiple sequential layers of learning algorithms, architecturally similar to neural networks of the b...

    Eddie de Dios, Muhaddisa Barat Ali in Machine Learning in Clinical Neuroscience (2022)

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    Chapter and Conference Paper

    Foundations of Machine Learning-Based Clinical Prediction Modeling: Part IV—A Practical Approach to Binary Classification Problems

    We illustrate the steps required to train and validate a simple, machine learning-based clinical prediction model for any binary outcome, such as, for example, the occurrence of a complication, in the statisti...

    Victor E. Staartjes, Julius M. Kernbach in Machine Learning in Clinical Neuroscience (2022)

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    Chapter and Conference Paper

    Deployment of Clinical Prediction Models: A Practical Guide to Nomograms and Online Calculators

    The use of predictive models within neurosurgery is increasing and many models described in published journal articles are made available to readers in formats such as nomograms and online calculators. The pre...

    Adrian E. Jimenez, James Feghali in Machine Learning in Clinical Neuroscience (2022)

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    Chapter and Conference Paper

    Foundations of Feature Selection in Clinical Prediction Modeling

    Selecting a set of features to include in a clinical prediction model is not always a simple task. The goals of creating parsimonious models with low complexity while, at the same time, upholding predictive pe...

    Victor E. Staartjes, Julius M. Kernbach in Machine Learning in Clinical Neuroscience (2022)

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    Chapter and Conference Paper

    Is My Clinical Prediction Model Clinically Useful? A Primer on Decision Curve Analysis

    Decision curve analysis is an increasingly popular method to assess the impact of a prediction model on medical decision making. The analysis provides a graphical summary. A basic understanding of a decision c...

    Hendrik-Jan Mijderwijk, Daan Nieboer in Machine Learning in Clinical Neuroscience (2022)

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    Chapter and Conference Paper

    A Discussion of Machine Learning Approaches for Clinical Prediction Modeling

    While machine learning has occupied a niche in clinical medicine for decades, continued method development and increased accessibility of medical data have led to broad diversification of approaches. These ran...

    Michael C. **, Adrian J. Rodrigues in Machine Learning in Clinical Neuroscience (2022)

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    Chapter and Conference Paper

    Machine Learning Algorithms in Neuroimaging: An Overview

    Machine learning (ML) and artificial intelligence (AI) applications in the field of neuroimaging have been on the rise in recent years, and their clinical adoption is increasing worldwide. Deep learning (DL) i...

    Vittorio Stumpo, Julius M. Kernbach in Machine Learning in Clinical Neuroscience (2022)

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    Chapter and Conference Paper

    Foundations of Lesion Detection Using Machine Learning in Clinical Neuroimaging

    This chapter describes technical considerations and current and future clinical applications of lesion detection using machine learning in the clinical setting. Lesion detection is central to neuroradiology an...

    Manoj Mannil, Nicolin Hainc, Risto Grkovski in Machine Learning in Clinical Neuroscience (2022)

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    Chapter and Conference Paper

    Foundations of Brain Image Segmentation: Pearls and Pitfalls in Segmenting Intracranial Blood on Computed Tomography Images

    Not only the time-dependent varying of signal intensity (i.e. haematoma evolution) characteristics of the intracranial blood in computed tomography images, but also the fluctuating image quality, the distortio...

    Antonios Thanellas, Heikki Peura in Machine Learning in Clinical Neuroscience (2022)

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    Chapter and Conference Paper

    Tackling the Complexity of Lesion-Symptoms Map**: How to Bridge the Gap Between Data Scientists and Clinicians?

    Accurate and predictive lesion-symptoms map** is a major goal in the field of clinical neurosciences. Recent studies have called for a reappraisal of the results given by the standard univariate voxel-based ...

    Emmanuel Mandonnet, Bertrand Thirion in Machine Learning in Clinical Neuroscience (2022)

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    Chapter and Conference Paper

    Foundations of Time Series Analysis

    For almost a century, classical statistical methods including exponential smoothing and autoregression integrated moving averages (ARIMA) have been predominant in the analysis of time series (TS) and in the pu...

    Jonas Ort, Karlijn Hakvoort, Georg Neuloh in Machine Learning in Clinical Neuroscience (2022)

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    Chapter and Conference Paper

    A Brief History of Machine Learning in Neurosurgery

    The history of machine learning in neurosurgery spans three decades and continues to develop at a rapid pace. The earliest applications of machine learning within neurosurgery were first published in the 1990s...

    Andrew T. Schilling, Pavan P. Shah in Machine Learning in Clinical Neuroscience (2022)

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    Chapter and Conference Paper

    Big Data in the Clinical Neurosciences

    The clinical neurosciences have historically been at the forefront of innovation, often incorporating the newest research methods into practice. This chapter will explore the adoption, implementation, and refi...

    G. Damian Brusko, Gregory Basil in Machine Learning in Clinical Neuroscience (2022)

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