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  1. No Access

    Chapter and Conference Paper

    Meta-level Verification of the Quality of Medical Guidelines Using Interactive Theorem Proving

    Requirements about the quality of medical guidelines can be represented using schemata borrowed from the theory of abductive diagnosis, using temporal logic to model the time-oriented aspects expressed in a gu...

    Arjen Hommersom, Peter Lucas, Michael Balser in Logics in Artificial Intelligence (2004)

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    Chapter and Conference Paper

    A History-Based Algebra for Quality-Checking Medical Guidelines

    In this paper, we propose a formal theory to describe the development of medical guideline text in detail, but at a sufficiently high level abstraction, in such way that essential elements of the guidelines ar...

    Arjen Hommersom, Peter Lucas, Patrick van Bommel in Artificial Intelligence in Medicine (2005)

  3. No Access

    Chapter and Conference Paper

    Combining Task Execution and Background Knowledge for the Verification of Medical Guidelines

    The use of a medical guideline can be seen as the execution of computational tasks, sequentially or in parallel, in the face of patient data. It has been shown that many of such guidelines can be represented a...

    Arjen Hommersom, Perry Groot, Peter Lucas in Research and Development in Intelligent Sy… (2007)

  4. No Access

    Chapter and Conference Paper

    The Role of Model Checking in Critiquing Based on Clinical Guidelines

    Medical critiquing systems criticise clinical actions performed by a physician. In order to provide useful feedback, an important task is to find differences between the actual actions and a set of ‘ideal’ act...

    Perry Groot, Arjen Hommersom, Peter Lucas in Artificial Intelligence in Medicine (2007)

  5. No Access

    Chapter and Conference Paper

    Actions with Failures in Interval Temporal Logic

    Failures are unavoidable in many circumstances. For example, an agent may fail at some point to perform a task in a dynamic environment. Robust systems typically have mechanisms to handle such failures. Tempor...

    Arjen Hommersom, Peter Lucas in Computational Logic in Multi-Agent Systems (2008)

  6. Chapter and Conference Paper

    Integrating Logical Reasoning and Probabilistic Chain Graphs

    Probabilistic logics have attracted a great deal of attention during the past few years. While logical languages have taken a central position in research on knowledge representation and automated reasoning, p...

    Arjen Hommersom, Nivea Ferreira in Machine Learning and Knowledge Discovery i… (2009)

  7. No Access

    Chapter and Conference Paper

    Toward Probabilistic Analysis of Guidelines

    In the formal analysis of health-care, there is little work that combines probabilistic and temporal reasoning. On the one hand, there are those that aim to support the clinical thinking process, which is char...

    Arjen Hommersom in Knowledge Representation for Health-Care (2011)

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    Chapter and Conference Paper

    Understanding the Co-occurrence of Diseases Using Structure Learning

    Multimorbidity, i.e., the presence of multiple diseases within one person, is a significant health-care problem for western societies: diagnosis, prognosis and treatment in the presence of of multiple diseases...

    Martijn Lappenschaar, Arjen Hommersom, Joep Lagro in Artificial Intelligence in Medicine (2013)

  9. No Access

    Chapter and Conference Paper

    Discovering Probabilistic Structures of Healthcare Processes

    Medical protocols and guidelines can be looked upon as concurrent programs, where the patient’s state dynamically changes over time. Methods based on verification and model-checking developed in the past have ...

    Arjen Hommersom, Sicco Verwer in Process Support and Knowledge Representati… (2013)

  10. No Access

    Chapter and Conference Paper

    Causal Independence Models for Continuous Time Bayesian Networks

    The theory of causal independence is frequently used to facilitate the assessment of the probabilistic parameters of probability distributions of Bayesian networks. Continuous time Bayesian networks are a rela...

    Maarten van der Heijden, Arjen Hommersom in Probabilistic Graphical Models (2014)

  11. No Access

    Chapter and Conference Paper

    Mining Hierarchical Pathology Data Using Inductive Logic Programming

    Considerable amounts of data are continuously generated by pathologists in the form of pathology reports. To date, there has been relatively little work exploring how to apply machine learning and data mining ...

    Tim Op De Beéck, Arjen Hommersom, Jan Van Haaren in Artificial Intelligence in Medicine (2015)

  12. No Access

    Chapter and Conference Paper

    Hybrid Time Bayesian Networks

    Capturing heterogeneous dynamic systems in a probabilistic model is a challenging problem. A single time granularity, such as employed by dynamic Bayesian networks, provides insufficient flexibility to capture...

    Manxia Liu, Arjen Hommersom in Symbolic and Quantitative Approaches to Re… (2015)

  13. No Access

    Chapter and Conference Paper

    A Prognostic Model of Glioblastoma Multiforme Using Survival Bayesian Networks

    Bayesian networks are attractive for develo** prognostic models in medicine, due to the possibility for modelling the multivariate relationships between variables that come into play in the care process. In ...

    Simon Rabinowicz, Arjen Hommersom, Raphaela Butz in Artificial Intelligence in Medicine (2017)

  14. No Access

    Chapter and Conference Paper

    Modeling the Dynamics of Multiple Disease Occurrence by Latent States

    The current availability of large volumes of health care data makes it a promising data source to new views on disease interaction. Most of the times, patients have multiple diseases instead of a single one (a...

    Marcos L. P. Bueno, Arjen Hommersom, Peter J. F. Lucas in Scalable Uncertainty Management (2018)

  15. No Access

    Chapter and Conference Paper

    Representing Hypoexponential Distributions in Continuous Time Bayesian Networks

    Continuous time Bayesian networks offer a compact representation for modeling structured stochastic processes that evolve over continuous time. In these models, the time duration that a variable stays in a sta...

    Manxia Liu, Fabio Stella, Arjen Hommersom in Information Processing and Management of U… (2018)

  16. No Access

    Chapter and Conference Paper

    Explaining the Most Probable Explanation

    The use of Bayesian networks has been shown to be powerful for supporting decision making, for example in a medical context. A particularly useful inference task is the most probable explanation (MPE), which p...

    Raphaela Butz, Arjen Hommersom, Marko van Eekelen in Scalable Uncertainty Management (2018)

  17. No Access

    Chapter and Conference Paper

    A Data-Driven Exploration of Hypotheses on Disease Dynamics

    Unsupervised learning is often used to obtain insight into the underlying structure of medical data. In this paper, we show that unsupervised methods, in particular hidden Markov models, can go beyond this by ...

    Marcos L. P. Bueno, Arjen Hommersom in Artificial Intelligence in Medicine (2019)

  18. No Access

    Chapter and Conference Paper

    Temporal Exceptional Model Mining Using Dynamic Bayesian Networks

    The discovery of subsets of data that are characterized by models that differ significantly from the entire dataset, is the goal of exceptional model mining. With the increasing availability of temporal data, ...

    Marcos L. P. Bueno, Arjen Hommersom in Advanced Analytics and Learning on Tempora… (2020)

  19. Chapter and Conference Paper

    Correction to: Gaining Insight into Determinants of Physical Activity Using Bayesian Network Learning

    “Gaining Insight into Determinants of Physical Activity Using Bayesian Network Learning” was previously published non-open access. It has now been changed to open access under a CC BY 4.0 license and the copyr...

    Simone C. M. W. Tummers, Arjen Hommersom in Artificial Intelligence and Machine Learni… (2021)

  20. Chapter and Conference Paper

    Gaining Insight into Determinants of Physical Activity Using Bayesian Network Learning

    Bayesian network modelling is applied to health psychology data in order to obtain more insight into the determinants of physical activity. This preliminary study discusses some challenges to apply general mac...

    Simone C. M. W. Tummers, Arjen Hommersom in Artificial Intelligence and Machine Learni… (2021)