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The overexpression of DSP1 in neurons induces neuronal dysfunction and neurodegeneration phenotypes in Drosophila
Dorsal switch protein 1(DSP1), a mammalian homolog of HMGB1, is firstly identified as a dorsal co-repressor in 1994. DSP1 contains HMG-box domain and...
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Contribution of plasma levels of VEGF-A and angiopoietin-2 in addition to a genetic variant in KCNAB1 to predict the risk of bevacizumab-induced hypertension
Bevacizumab-induced hypertension poses a therapeutic challenge and identifying biomarkers for hypertension can enhance therapy safety. Lower plasma...
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Simultaneous cannabis and psychedelic use among festival and concert attendees in Colorado: characterizing enhancement and adverse reactions using mixed methods
BackgroundMost studies examining the simultaneous use of cannabis with other drugs have focused on cannabis and alcohol, with fewer studies examining...
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Patterns of Pregabalin Users from Substance Abuse Treatment Facilities: Results from the French OPPIDUM Program from 2008 to 2022
IntroductionIn recent years, pregabalin has received growing attention due to its abuse liability. The aim of this study was to further characterize...
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The influence of PER3 VNTR genotypes on the age of onset in a group of bipolar I disorder patients: an exploratory study
BackgroundPER3 is a circadian gene that contains a variable number of tandem repeats (VNTR) which codifies for three genotypes: 4/4; 4/5; and 5/5...
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Combining app-based behavioral therapy with electronic cigarettes for smoking cessation: a study protocol for a single-arm mixed-methods pilot trial
BackgroundCigarette smoking remains a leading cause of preventable illness and death, underscoring the need for effective evidence-based smoking...
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Understanding the epidemiology and perceived efficacy of cannabis use in patients with chronic musculoskeletal pain
BackgroundThe belief that cannabis has analgesic and anti-inflammatory properties continues to attract patients with chronic musculoskeletal (MSK)...
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A Long-Term Safety and Tolerability Study of TV-46000 for Subcutaneous Use in Patients with Schizophrenia: A Phase 3, Randomized, Double-Blinded Clinical Trial
BackgroundTV-46000 is a long-acting subcutaneous antipsychotic (LASCA) formulation of risperidone that is approved by the United States Food and Drug...
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(Auto‑)Immunität bei fokaler Epilepsie: Mechanismen (auto‑)immun-inflammatorischer epileptogener Neurodegeneration
ObjectiveWhile the neuronal mechanisms of epileptic hyperexcitability (HE) have been studied in detail, recent findings suggest that extraneuronal,...
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MicroRNAs as the pivotal regulators of Temozolomide resistance in glioblastoma
Glioblastoma (GBM) is an aggressive nervous system tumor with a poor prognosis. Although, surgery, radiation therapy, and chemotherapy are the...
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Immunologische Grundlagen neurologischer Erkrankungen
BackgroundNeurodegenerative diseases represent an increasing challenge in ageing societies, as only limited treatment options are currently available.
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The State of Synthetic Cannabinoid Medications for the Treatment of Pain
Synthetic cannabinoids are compounds made in the laboratory to structurally and functionally mimic phytocannabinoids from the Cannabis sativa L . ...
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When, Why and How to Re-challenge Clozapine in Schizophrenia Following Myocarditis
Clozapine-induced myocarditis (CIM) is among the most important adverse events limiting the use of clozapine as the most effective treatment for...
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Risk of anthracycline-induced cardiac dysfunction in adolescent and young adult (AYA) cancer survivors: role of genetic susceptibility loci
There is a known genetic susceptibility to anthracycline-induced cardiac dysfunction in childhood cancer survivors, but this has not been adequately...
