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The association between screen time exposure, parent depression, and development of social communication skills among preschool children in Qassim Region
BackgroundScreen exposure among children continues to increase worldwide. It has negative effects on children of developmental age, including...
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Towards an informed research agenda for the field of personality disorders by experts with lived and living experience and researchers
BackgroundWe describe a collection of themes for a research agenda for personality disorders that was originally formulated for the ESSPD Borderline...
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Spinal muscular atrophy caused by compound heterozygous SMN1 mutations: two cases and literature review
Spinal muscular atrophy (SMA) is a rare neuromuscular disease, which is characterized by the degeneration of motor neurons, leading to symmetrical...
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The risks for major psychiatric disorders in the siblings of probands with major depressive disorder
Using a case-controlled study including siblings of major depression (MD) and control probands, born 1970–1990 and followed through 2018, we sought...
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Phenotypic and mutational spectrum of 17 Chinese patients with Menkes Disease
BackgroundMenkes Disease (MD) is a fatal X-linked recessive disorder caused by mutations in the ATP7A gene. Severe cases typically die before the age...
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Aticaprant, a kappa opioid receptor antagonist, and the recovered ‘interest and pleasure’ in the concept of major depressive disorder
Lack of positive mood and anhedonia probably are the most specific depressive symptoms. Anhedonia is a multifaceted concept: the clinical language...
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Predictors of changes in marijuana consumption in Germany during the covid-19 pandemic
During the Covid-19 pandemic Germany experienced its first increase in the proportion of heavy cannabis users since 1995. With the expected...
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What Chemsex does to the brain - neural correlates (ERP) regarding decision making, impulsivity and hypersexuality
Chemsex describes the use of specific substances (methamphetamine, GHB/GBL, mephedrone, ketamine) which initiate or enhance sexual experiences and is...
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Increased anti-correlation between the left dorsolateral prefrontal cortex and the default mode network following Stanford Neuromodulation Therapy (SNT): analysis of a double-blinded, randomized, sham-controlled trial
SNT is a high-dose accelerated intermittent theta-burst stimulation (iTBS) protocol coupled with functional-connectivity-guided targeting that is an...
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Thalamocortical functional connectivity and rapid antidepressant and antisuicidal effects of low-dose ketamine infusion among patients with treatment-resistant depression
Previous studies have shown an association between the thalamocortical dysconnectivity and treatment-resistant depression (TRD). Whether a single...
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Acceptability and Feasibility of the Anger and Irritability Management Skills Mobile App Among Veterans with Posttraumatic Stress Disorder: A Mixed-Methods Pilot Study
Problematic anger as a symptom of posttraumatic stress disorder (PTSD) is prevalent in military populations, including Veterans. Existing anger...
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Individualized time windows enhance TMS-EEG signal characterization and improve assessment of cortical function in schizophrenia
Transcranial magnetic stimulation and electroencephalography (TMS-EEG) recordings are crucial to directly assess cortical excitability and inhibition...
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Assessment of resting cerebral perfusion between methamphetamine-associated psychosis and schizophrenia through arterial spin labeling MRI
Objective: The clinical manifestations of methamphetamine (METH)-associated psychosis (MAP) and acute paranoid schizophrenia (SCZ) are similar. This...
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Targeting Neurotransmitter Systems in Bipolar Disorder: A comprehensive Review of novel pharmacological approaches
Purpose of ReviewTo critically assess the efficacy of novel pharmacological interventions in managing manic or hypomanic episodes in adult patients...
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Successful treatment with efgartigimod as an add-on therapy in acute attack of anti-AQP4 antibody-positive NMOSD: a case report
BackgroundNeuromyelitis Optica Spectrum Disorder (NMOSD) is an autoimmune demyelinating disease characterized by recurrent myelitis and optic...
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Obstructive Sleep Apnea: Relationship Between Mild Neurocognitive Impairments and Quality of Life
Patients with obstructive sleep apnea might have neurocognitive impairments and reduced quality of life. Considering the same, this study was...
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Late adolescent outcomes of different developmental trajectories of ADHD symptoms in a large longitudinal study
There exists substantial heterogeneity in the developmental trajectories of ADHD symptoms, with distinctions often made between persistent versus...
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Effects of psychedelic, DOI, on nucleus accumbens dopamine signaling to predictable rewards and cues in rats
Psychedelics produce lasting therapeutic responses in neuropsychiatric diseases suggesting they may disrupt entrenched associations and catalyze...
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Online Group Psychotherapy: A Systematic Review
IntroductionThere is a need within counselling and psychotherapy to ensure their ability to respond to endemic presences such as the COVID-19...
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Pulsed nicotine infusions as a model for smoking: validating a tool to explore nicotine thresholds in humans
RationaleNo previous studies examined the discriminative stimulus effects of intravenous (IV) nicotine in humans.
ObjectivesTo evaluate a pulsed IV...