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What to Measure in Aneurysmal Subarachnoid Haemorrhage Research—An International Delphi Survey
Aneurysmal subarachnoid haemorrhage (aSAH) is a devastating condition with high mortality and morbidity. The outcome measures used in aSAH clinical...
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Neuroprotective and vasoprotective effects of herb pair of Zhiqiao-Danggui in ischemic stroke uncovered by LC-MS/MS-based metabolomics approach
Ischemic stroke is the most important cause of disability and death worldwide, but current treatments remain limited. Traditional Chinese medicine...
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Inter-joint coordination with and without dopaminergic medication in Parkinson’s disease: a case-control study
BackgroundHow the joints exactly move and interact and how this reflects PD-related gait abnormalities and the response to dopaminergic treatment is...
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Assessment of Innovative Pharmacological Targets in Schizophrenia
Purpose of reviewSchizophrenia is a disorder with an approximate prevalence of 1% associated with great impairments in daily life functioning and...
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Intelligent ankle–foot prosthesis based on human structure and motion bionics
The ankle–foot prosthesis aims to compensate for the missing motor functions by fitting the motion characteristics of the human ankle, which...
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Nerve Regeneration Through Differentiation of Endometrial-Derived Mesenchymal Stem Cells into Nerve-Like Cells Using Polyacrylonitrile/Chitosan Conduit and Berberine in a Rat Sciatic Nerve Injury Model
Nervous injuries are common in humans. One of the most advanced treatment methods is neural tissue engineering. This research aims to utilize...
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MAMs and Mitochondrial Quality Control: Overview and Their Role in Alzheimer’s Disease
Alzheimer’s disease (AD) represents the most widespread neurodegenerative disorder, distinguished by a gradual onset and slow progression, presenting...
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Genome-wide association study on meningioma risk in Japan: a multicenter prospective study
PurposeAlthough meningiomas are the most common primary intracranial tumors, their genetic etiologies have not been fully elucidated. To date, only...
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Plasma Biomarkers of Alzheimer’s Disease and Neurodegeneration According to Sociodemographic Characteristics and Chronic Health Conditions
Ultrasensitive assays have been developed which enable biomarkers of Alzheimer’s disease pathology and neurodegeneration to be measured in blood....
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Intermittent Fasting Improves Social Interaction and Decreases Inflammatory Markers in Cortex and Hippocampus
Autism spectrum disorder (ASD) is a psychiatric condition characterized by reduced social interaction, anxiety, and stereotypic behaviors related to...
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Factors leading to falls in transfemoral prosthesis users: a case series of prosthesis-side stumble recovery responses
BackgroundFalls due to stumbling are prevalent for transfemoral prosthesis users and may lead to increased injury risk. This preliminary case series...
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The overexpression of DSP1 in neurons induces neuronal dysfunction and neurodegeneration phenotypes in Drosophila
Dorsal switch protein 1(DSP1), a mammalian homolog of HMGB1, is firstly identified as a dorsal co-repressor in 1994. DSP1 contains HMG-box domain and...
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Impact and Interrelationships of Striatal Proteins, EPHB2, OPRM1, and PER2 on Mild Cognitive Impairment
With the global increase in life expectancy, there has been a rise in the incidence of cognitive impairments attributed to diverse etiologies....
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Glucagon-like peptide-1 (GLP-1) receptor agonists for headache and pain disorders: a systematic review
BackgroundGlucagon-like peptide-1 (GLP-1) plays a crucial role in metabolic disorders by enhancing insulin secretion, inhibiting glucagon release,...
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Beneficial Effect of Pretreatment Hyperosmolality on Outcome in Severe Traumatic Brain Injury: Evidence from a South Korean Multicenter Registry and Propensity Score Matching Analysis
BackgroundHyperosmolar therapy has long been a cornerstone in managing increased intracranial pressure and improving outcomes in severe traumatic...
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Elucidating the therapeutic mechanism of betanin in Alzheimer’s Disease treatment through network pharmacology and bioinformatics analysis
Betanin, a natural compound with anti-inflammatory and antioxidant properties, has shown promise in mitigating Alzheimer’s disease (AD) by reducing...
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Dissociable functional responses along the posterior-anterior gradient of the frontal and parietal cortices revealed by parametric working memory and training
While the storage capacity is limited, accumulating studies have indicated that working memory (WM) can be improved by cognitive training. However,...
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The interplay of inflammation and remyelination: rethinking MS treatment with a focus on oligodendrocyte progenitor cells
BackgroundMultiple sclerosis (MS) therapeutic goals have traditionally been dichotomized into two distinct avenues: immune-modulatory-centric...
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Early biomarkers in the presymptomatic phase of cognitive impairment: changes in the endocannabinoidome and serotonergic pathways in Alzheimer's-prone mice after mTBI
BackgroundDespite extensive studies on the neurobiological correlates of traumatic brain injury (TBI), little is known about its molecular...
