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Boosting working memory in the elderly: driving prefrontal theta–gamma coupling via repeated neuromodulation
The escalating global burden of age-related neurodegenerative diseases and associated healthcare costs necessitates innovative interventions to...
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Multimodal training protocols on unstable rather than stable surfaces better improve dynamic balance ability in older adults
BackgroundThere has been growing interest in using unstable devices in training protocols. This study aimed to assess the effectiveness of two...
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Nuclear alpha-synuclein accelerates cell senescence and neurodegeneration
BackgroundThe progression of Parkinson’s disease (PD) is related to ageing. The accumulation of nuclear alpha-synuclein (α-syn) may accelerate the...
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Relationship between quantitative physical activity and deterioration of locomotive function: a cross-sectional study using baseline data from a cohort
BackgroundIn aged society, health policies aimed at extending healthy life expectancy are critical. Maintaining physical activity is essential to...
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Childhood intra- and extra-familial maltreatment and later-life trajectories of depressive symptoms: evidence from China
BackgroundBoth late-life depression and childhood maltreatment have become major global public health issues, given their prevalence and...
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Differences of anticholinergic drug burden between older hospitalized patients with and without delirium: a systematic review and meta-analysis based on prospective cohort studies
ObjectivesThis review aims to comprehensively summarize the differences in anticholinergic drug burden (ADB) scores between older hospitalized...
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What determines informal care need among community-dwelling older adults in China? Results from a longitudinal study
BackgroundWith an intensified aging population and an associated upsurge of informal care need in China, there is an ongoing discussion around what...
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Maternal α-casein deficiency extends the lifespan of offspring and programmes their body composition
Early nutrition has significant effects on physiological outcomes during adult life. We have analysed the effect of maternal α-casein (CSN1S1)...
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Association between antidepressant use and delirium in older adults: an analysis of the World Health Organization’s global pharmacovigilance database
BackgroundPsychoactive drugs frequently cause delirium adverse events in older adults. However, few data on the relationship between antidepressants...
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Plasma Biomarkers of Alzheimer’s Disease and Neurodegeneration According to Sociodemographic Characteristics and Chronic Health Conditions
Ultrasensitive assays have been developed which enable biomarkers of Alzheimer’s disease pathology and neurodegeneration to be measured in blood....
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Universal Prevention of Dementia in Italy: A Document Analysis of the 21 Italian Regional Prevention Plans
BackgroundUp to 40% of dementia cases are theoretically avoidable and population-level interventions (i.e., universal prevention) are a key component...
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No Association Found: Adverse Childhood Experiences and Cognitive Impairment in Older Australian Adults
ObjectiveThis study aimed to investigate the relationship between childhood adversity and cognitive impairment in older adults.
Methods ...
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Acceptability and preliminary effects of the volunteer-supported Meaningful Moments program to engage older adults with advanced dementia on a hospital-based specialized dementia care unit: a mixed methods study
BackgroundNamaste Care offers practical skills for healthcare providers, volunteers, and families to meaningfully engage individuals with dementia in...
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Association between sleep duration and possible sarcopenia in middle-aged and elderly Chinese individuals: evidence from the China health and retirement longitudinal study
BackgroundSarcopenia is a common cause of disability in the aging population, and managing sarcopenia is an important step in building intrinsic...
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Atypical chronic myeloid leukemia found in a patient with eosinophilia for six years: a case report
BackgroundAtypical chronic myeloid leukemia (aCML) is a highly aggressive type of blood cancer that falls under the category of...
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The mouse Social Frailty Index (mSFI): a novel behavioral assessment for impaired social functioning in aging mice
Various approaches exist to quantify the aging process and estimate biological age on an individual level. Frailty indices based on an age-related...
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Self-perceptions of aging, physical activity, and depressive symptoms in older community residents with varied neighborhood walkability in Taiwan
BackgroundPrior research has identified the mediating effect of physical activity in the relationship between self-perceptions of aging and physical...
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Longitudinal analysis on inflammatory markers and frailty progression: based on the English longitudinal study of aging
PurposeFrailty is a common health state that is closely linked to adverse health outcomes in aging society. Although many inflammatory biomarkers...
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Age-related effects on absolute and relative isokinetic knee extensor strength in community-dwelling older men and women at a French geriatric day hospital
PurposeIsokinetic knee extensor strength is poorly evaluated in geriatric day hospitals (GDHs), despite its potential functional significance...
