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Identification of volatile metabolites produced from levodopa metabolism by different bacteria strains of the gut microbiome
Interspecies pathways in the gut microbiome have been shown to metabolize levodopa, the primary treatment for Parkinson’s disease, and reduce its...
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C4-like Sesuvium sesuvioides (Aizoaceae) exhibits CAM in cotyledons and putative C4-like + CAM metabolism in adult leaves as revealed by transcriptome analysis
BackgroundThe co-occurrence of C 4 and CAM photosynthesis in a single species seems to be unusual and rare. This is likely due to the difficulty in...
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Preclinical and clinical advances to overcome hypoxia in glioblastoma multiforme
Glioblastoma multiforme (GBM) is the most common adult primary brain tumor. The standard clinical treatment of GBM includes a maximal surgical...
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Age-related dysregulation of CXCL9/10 in monocytes is linked to impaired innate immune responses in a mouse model of Staphylococcus aureus osteomyelitis
BackgroundAge-associated impairments in innate immunity are believed to be a causative factor responsible for severe pathogenesis of Staphylococcus...
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CRISPR screens in 3D tumourspheres identified miR-4787-3p as a transcriptional start site miRNA essential for breast tumour-initiating cell growth
Our study employs pooled CRISPR screens, integrating 2D and 3D culture models, to identify miRNAs critical in Breast Cancer (BC) tumoursphere...
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Unveiling the Role of Angiosperm Pollen Morphology in Attachment to the Moth (Lepidoptera) Proboscides
AbstractThe current study aims to understand the role of various morphological features of pollen grains in attachment with moth proboscides. To test...
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Identification of Tissue Expression Characteristics of Pig ALKBH5 and Its Association with Pathogenic Microbial Infection
AbstractN 6 -methyladenosine (m 6 A) as a reversible RNA modification has become a new direction and hotspot of RNA epigenetics research in the field of...
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Sexual Size Dimorphism in Buthus tunetanus (Scorpiones: Buthidae) from Tunisia
AbstractScorpions are known to exhibit sexual size dimorphism, but data is still lacking from a large number of species throughout the world. Such...
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Evaluation of heritability partitioning approaches in livestock populations
BackgroundHeritability partitioning approaches estimate the contribution of different functional classes, such as coding or regulatory variants, to...
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Growth Characteristics of 10 Deep-Sea Demersal Scorpaenoid Fish Species from the Arabian Sea: Insights for Database Update and Fisheries Management
AbstractThe present study provides length-weight relationships (LWRs) and condition factors (Kn) estimates for ten deep-sea scorpaeniform fishes...
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DNA Barcoding of Tree Frogs: Testing the Existence of Two Mitochondrial Lineages of Hyla savignyi
AbstractDNA barcoding is a popular approach that can aid in identifying species and has led to the discovery of many new amphibian species. In this...
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Evaluation of the Irrigation Water Quality of Beressa River, North West Ethiopia
Beressa River is facing a problem due to uncontrolled discharge of liquid wastes from domestics and industries. Therefore, the study was conducted to...
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Modelling Role of Protective and Nonprotective HLA Allele Inducing Different HIV Infection Outcomes
Human immunodeficiency virus (HIV) infects CD4+ cells and causes progressive immune function failure, and CD8+ cells lyse infected CD4+ cell via...
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A novel deep-benthic sea cucumber species of Benthodytes (Holothuroidea, Elasipodida, Psychropotidae) and its comprehensive mitochondrial genome sequencing and evolutionary analysis
BackgroundThe holothurians, commonly known as sea cucumbers, are marine organisms that possess significant dietary, nutritional, and medicinal value....
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Biodiversity of Epibenthic Invertebrates in the Subtidal Mekong Estuaries, Southern Vietnam with Remarks on Decapod Assemblages
AbstractEpibenthic invertebrates in three estuaries of the Mekong River, namely Co Chien, Ba Lai, and Cua Dai, were sampled for ecological analysis...
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Phylogenetic Inference from 16S rRNA Gene Sequencing in Chromosome Races of the Genus Nannospalax Species (Rodentia: Spalacidae)
AbstractIn this study, we aimed to develop a species-level phylogeny for the Nannospalax genus, identify cryptic species that are difficult to...
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Rutin Ameliorates Toxoplasma gondii-Induced Brain Tissue Damage via Inhibiting P2X7R/NLRP3 Pro-Inflammatory and Enhancing PI3K/AKT/Nrf2/HO-1 Antioxidant Signaling Pathway
AbstractBain damage caused by Toxoplasma gondii ( T. gondii ) is associated with increased inflammatory response and oxidative stress. Rutin, a...
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Recent advances in the pathogenesis and prevention strategies of dental calculus
Dental calculus severely affects the oral health of humans and animal pets. Calculus deposition affects the gingival appearance and causes...
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GPR116 alleviates acetaminophen-induced liver injury in mice by inhibiting endoplasmic reticulum stress
BackgroundAcetaminophen (APAP) overdose is a significant contributor to drug-induced liver injury worldwide. G-protein–coupled receptor 116 (GPR116)...
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The eEF2 kinase coordinates the DNA damage response to cisplatin by supporting p53 activation
Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) is a stress-responsive hub that inhibits the translation elongation factor eEF2, and...
