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Inhibition of PKC-δ retards kidney fibrosis via inhibiting cGAS-STING signaling pathway in mice
Kidney fibrosis is considered to be the ultimate aggregation pathway of chronic kidney disease (CKD), but its underlying mechanism remains elusive....
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The brachioradialis longus: an unreported accessory form of the brachioradialis muscle
The brachioradialis muscle (BR) belongs to the lateral forearm muscle. Typically, the radial nerve innervates it. BR morphological variability, such...
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Mechanistic and therapeutic perspectives of non-coding RNA-modulated apoptotic signaling in diabetic retinopathy
Diabetic retinopathy (DR), a significant and vision-endangering complication associated with diabetes mellitus, constitutes a substantial portion of...
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The ethics of artificial intelligence systems in healthcare and medicine: from a local to a global perspective, and back
Artificial intelligence systems (ai-systems) (e.g. machine learning, generative artificial intelligence), in healthcare and medicine, have been...
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Aqp4a and Trpv4 mediate regulatory cell volume increase for swimming maintenance of marine fish spermatozoa
Volume regulation is essential for cell homeostasis and physiological function. Amongst the sensory molecules that have been associated with volume...
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Temporal changes in the morphological and microbial diversity of biofilms on the surface of a submerged stone in the Danube River
Epilithic biofilms are ubiquitous in large river environments and are crucial for biogeochemical processes, but their community structures and...
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A Diffusion-Based Approach for Simulating Forward-in-Time State-Dependent Speciation and Extinction Dynamics
We establish a general framework using a diffusion approximation to simulate forward-in-time state counts or frequencies for cladogenetic...
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Endogenous LXR signaling controls pulmonary surfactant homeostasis and prevents lung inflammation
Lung type 2 pneumocytes (T2Ps) and alveolar macrophages (AMs) play crucial roles in the synthesis, recycling and catabolism of surfactant material, a...
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In vivo photocontrol of orexin receptors with a nanomolar light-regulated analogue of orexin-B
Orexinergic neurons are critically involved in regulating arousal, wakefulness, and appetite. Their dysfunction has been associated with slee**...
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Human cytomegalovirus infection impairs neural differentiation via repressing sterol regulatory element binding protein 2-mediated cholesterol biosynthesis
Congenital human cytomegalovirus (HCMV) infection is a major cause of abnormalities and disorders in the central nervous system (CNS) and/or the...
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Rankl genetic deficiency and functional blockade undermine skeletal stem and progenitor cell differentiation
BackgroundSkeletal Stem Cells (SSCs) are required for skeletal development, homeostasis, and repair. The perspective of their wide application in...
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Preclinical Therapeutic Efficacy of Extracellular Vesicles Derived from Adipose-Derived Mesenchymal Stromal/Stem Cells in Diabetic Wounds: a Systematic Review and Meta-Analysis
Extracellular vesicles isolated from adipose tissue-derived mesenchymal stromal/stem cells (ADSC-EVs) have demonstrated promising potential in wound...
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Unconventional posttranslational modification in innate immunity
Pattern recognition receptors (PRRs) play a crucial role in innate immunity, and a complex network tightly controls their signaling cascades to...
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Multiple biotic factors mediate the invasion success of Chromolaena odorata
Community resistance plays a crucial role in the successful invasion of alien plants. However, our understanding of how soil legacy effects of native...
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Origin recognition complex 6 overexpression promotes growth of glioma cells
The discovery of novel oncotargets for glioma is of immense significance. We here explored the expression patterns, biological functions, and...
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Proteomic analysis of lung responses to SARS-CoV-2 infection in aged non-human primates: clinical and research relevance
With devastating health and socioeconomic impact worldwide, much work is left to understand the Coronavirus Disease 2019 (COVID-19), with emphasis in...
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Integrating brain function and structure in the study of the human attentional networks: a functionnectome study
Attention is a heterogeneous function theoretically divided into different systems. While functional magnetic resonance imaging (fMRI) has...
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Microstructural properties in subacute aphasia: concurrent and prospective relationships underpinning recovery
Background: Few investigations examined the relationship between microstructural white matter integrity and subacute post-stroke linguistic...
