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A Mathematical Model for Fibrous Dysplasia: The Role of the Flow of Mutant Cells
Fibrous dysplasia (FD) is a mosaic non-inheritable genetic disorder of the skeleton in which normal bone is replaced by structurally unsound...
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Facile biotic/abiotic sandwich detection system for the highly sensitive detection of human serum albumin and glycated albumin
Quantifying glycated albumin (GA) levels in the blood is crucial for diagnosing diabetes because they strongly correlate with blood glucose...
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Cattleya attenboroughiana (Orchidaceae: Laeliinae): a new species from the Diamantina Plateau, Minas Gerais, Brazil
A new species of Cattleya ser. Parviflorae (Orchidaceae) is here described from the campos rupestres of the Diamantina Plateau, part of the Espinhaço...
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A Ratiometric Benzimidazole-Based Fluorescent Probe for The Recognition of Phosgene in Solution and Gaseous Phases
Considering the high toxicity and widespread application of phosgene, there is an urgent need to develop a simple and sensitive method for detecting...
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A novel class of indole derivatives: enhanced bioavailability, permeability, and antioxidant efficacy for thromboembolic disease therapy
Free radicals like reactive oxygen species (ROS) and reactive nitrogen species (RNS) cause cellular damage and contribute to thromboembolic diseases...
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Heritability and correlations for honey yield, handling ease, brood quantity, and traits related to resilience in a French honeybee population
There is growing interest in selective breeding of the honeybee, resulting in the emergence of new breeding projects, often with an emphasis on...
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DAP12 interacts with RER1 and is retained in the secretory pathway before assembly with TREM2
DNAX-activating protein of 12 kDa (DAP12) is a transmembrane adapter protein expressed in lymphoid and myeloid lineage cells. It interacts with...
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A flexible glucose biosensor modified by reduced-swelling and conductive zwitterionic hydrogel enzyme membrane
This paper reports a flexible glucose biosensor which is modified by a reduced-swelling and conductive zwitterionic hydrogel enzyme membrane that...
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Targeting oncogene-induced cellular plasticity for tumor therapy
Cellular plasticity, the remarkable adaptability of cancer cells to survive under various stress conditions, is a fundamental hallmark that...
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SNCA is a potential therapeutic target for COVID-19 infection in diffuse large B-cell lymphoma patients
Cuprotosis related genes (CRGs) have been proved to be potential therapeutic targets for coronavirus disease 2019 (COVID-19) and cancer, but their...
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Building a translational cancer dependency map for The Cancer Genome Atlas
Cancer dependency maps have accelerated the discovery of tumor vulnerabilities that can be exploited as drug targets when translatable to patients....
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p53 at the crossroads of tumor immunity
The p53 tumor suppressor protein has a plethora of cell-intrinsic functions and consequences that impact diverse cell types and tissues. Recent...
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Isolation and characterization of a two-coordinate phosphinidene oxide
Nitroso compounds, R–N=O, are common intermediates in organic synthesis, and are typically amenable to storage and manipulation at ambient...
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Long-term biotic homogenization in the East African Rift System over the last 6 million years of hominin evolution
Eastern Africa preserves the most complete record of human evolution anywhere in the world but we have little knowledge of how long-term...
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The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation
Multiple neurodegenerative diseases are characterized by aberrant proteinaceous accumulations of tau. Here, we report a RING-in-between-RING-type E3...
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Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition
Therapy resistance and metastasis, the most fatal steps in cancer, are often triggered by a (partial) activation of the epithelial–mesenchymal...
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Heterotrimeric collagen helix with high specificity of assembly results in a rapid rate of folding
The most abundant natural collagens form heterotrimeric triple helices. Synthetic mimics of collagen heterotrimers have been found to fold slowly,...
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Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health
Glutamine and glutamate are interconverted by several enzymes and alterations in this metabolic cycle are linked to cardiometabolic traits. Herein,...
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Vitamin C inactivates c-Jun N-terminal kinase to stabilize heart and neural crest derivatives expressed 1 (Hand1) in regulating placentation and maintenance of pregnancy
Vitamin C (VC) serves as a pivotal nutrient for anti-oxidation process, metabolic responses, and stem cell differentiation. However, its precise...
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Exploring the challenges of RNAi-based strategies for crop protection
RNA silencing (or RNA interference, RNAi) initiated by double-stranded RNAs is a conserved mechanism for regulating gene expression in eukaryotes....
