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Knockout Transporter Cell Lines to Assess Substrate Potential Towards Efflux Transporters
P-glycoprotein (P-gp), breast cancer resistance protein (BCRP) and multidrug resistance transporter 2 (MRP2) are efflux transporters involved in the...
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CONUT score as a predictor for anamorelin efficacy in patients with cancer cachexia receiving chemotherapy
BackgroundAnamorelin is expected to improve cancer cachexia by increasing lean body mass (LBM) due to increased appetite and protein synthesis....
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Elucidating CTLA-4’s role in tumor immunity: a comprehensive overview of targeted antibody therapies and clinical developments
Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) emerges as a key single-chain transmembrane glycoprotein predominantly expressed in effector T...
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Dehydration of Tetrahydrofurfuryl Alcohol Into Dihydropyran on γ-Al2O3 Catalyst: Reaction Monitoring by In Situ DRIFT Spectroscopy
In this study, in situ diffuse reflectance infrared Fourier transform (DRIFT) spectroscopy was used to analyze the surface reactivity during the...
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Influence of ensitrelvir or nirmatrelvir/ritonavir on tacrolimus clearance in kidney transplant recipients: a single-center case series
BackgroundAmong the oral antivirals used for treating patients with mild-to-moderate novel coronavirus disease 2019 (COVID-19),...
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A model for identifying potentially inappropriate medication used in older people with dementia: a machine learning study
BackgroundOlder adults with dementia often face the risk of potentially inappropriate medication (PIM) use. The quality of PIM evaluation is hindered...
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Mitochondrial targeted antioxidants as potential therapy for huntington’s disease
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by an expansion in CAG repeat on huntington (Htt) gene, leading to a...
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Intact NMR Approach Quickly Reveals Synchronized Microstructural Changes in Oil-in-Water Nanoemulsion Formulations
A soft-core oil-in-water (o/w) nanoemulsion (NE) is composed of nanometer (nm) sized oil droplets, stabilized by a surfactant layer and dispersed in...
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Pharmacokinetic Modeling of the Effect of Tariquidar on Ondansetron Disposition into the Central Nervous System
PurposeSerotonin (5-HT 3 ) receptor antagonists are promising agents for treatment of neuropathic pain. However, insufficient drug exposure at the...
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Insulin resistance, clinical presentation and resistance to selective serotonin and noradrenaline reuptake inhibitors in major depressive disorder
BackgroundThe understanding of mechanisms underlying non-response to antidepressants is limited. The latest data highlights the role of insulin...
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Medication errors in older patients: a pharmacovigilance perspective
IntroductionDrug regulatory agencies are particularly interested in pharmacovigilance data relating to medication errors (MEs) involving a...
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Take an individualized approach when managing women of reproductive age with uterine fibroids
Uterine fibroids are the most common gynaecological tumour in women of reproductive age and can cause heavy menstrual bleeding, anaemia, pelvic pain,...
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Pharmacokinetics and Histotoxic Profile of a Novel Azithromycin-Loaded Lipid-Based Nanoformulation
Azithromycin traditional formulations possesses poor oral bioavailability which necessitates development of new formulation with enhanced...
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Long-term topical corticosteroid treatment for atopic dermatitis: an in-depth analysis of safety, efficacy, withdrawal, and patient experiences
Atopic dermatitis, often referred to as eczema, is classified as a chronic inflammatory skin disorder with increasing prevalence. Topical...
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Distribution Clearance: Significance and Underlying Mechanisms
PurposeEvaluation of distribution kinetics is a neglected aspect of pharmacokinetics. This study examines the utility of the model-independent...
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Formulation and Antimycotic Evaluation of Colloidal Itraconazole-Loaded Metered Dose Sprays for Treating Superficial Mycoses
Commercial topical formulations containing itraconazole (poorly water soluble), for mycotic infections, have poor penetration to infection sites...
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Enantiomeric resolution of three profen drugs using direct thin-layer chromatographic method
This study presents the enantiomeric resolution of three profen drugs, viz ., flurbiprofen (FLB), fenoprofen, and zaltoprofen by employing...
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Investigation of cholinesterase and α-glucosidase enzyme activities, and molecular docking and dft studies for 1,2-disubstituted cyclopentane derivatives with phenyl and benzyl units
Six known products ( 4 – 9 ) were prepared from reaction of adipoyl chloride with 1,2,3-trimethoxybenzene according to the literature. From...
