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Methylprednisolone Modulates the Tfr/Tfh ratio in EAE-Induced Neuroinflammation through the PI3K/AKT/FoxO1 and PI3K/AKT/mTOR Signalling Pathways
Methylprednisolone (MP) is a potent glucocorticoid that can effectively inhibit immune system inflammation and brain tissue damage in Multiple...
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The determinants of mental health inequalities between Chinese migrants and non-migrants during the Shanghai 2022 lockdown: a Blinder-Oaxaca decomposition
BackgroundThe mental health inequality between migrants and non-migrants was exacerbated by the COVID-19 pandemic. Identifying key determinants of...
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Increasing Diversity, Equity, Inclusion, and Accessibility in Rare Disease Clinical Trials
Diversity, equity, inclusion, and accessibility (DEIA) are foundational principles for clinical trials and medical research. In rare diseases...
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Short and long-term acceptability and efficacy of extended-release cornstarch in the hepatic glycogen storage diseases: results from the Glyde study
BackgroundHypoglycaemia is the primary manifestation of all the hepatic types of glycogen storage disease (GSD). In 2008, Glycosade ® , an...
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ErbB4 deficiency exacerbates olfactory dysfunction in an early-stage Alzheimer’s disease mouse model
Olfactory dysfunction is increasingly recognized as an early indicator of Alzheimer’s disease (AD). Aberrations in GABAergic function and the...
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Emodin alleviates intestinal ischemia–reperfusion injury through antioxidant stress, anti-inflammatory responses and anti-apoptosis effects via Akt-mediated HO-1 upregulation
BackgroundIntestinal ischemia–reperfusion (I/R) injury is a severe vascular emergency. Previous research indicated the protective effects of Emodin...
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Probabilistic models of profiles for voting by evaluation
Considering voting rules based on evaluation inputs rather than preference rankings modifies the paradigm of probabilistic studies of voting...
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Partitionable choice functions and stability
We consider the two-sided many-to-one matching problem and introduce a class of preferences reflecting natural forms of complementarities. For...
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The Association of Gabapentin Initiation with Cognitive and Behavioral Changes in Older Adults with Cognitive Impairment: A Retrospective Cohort Study
BackgroundAlthough gabapentin has been increasingly prescribed to older adults, the relation between gabapentin initiation and longer-term...
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New studies with stable gastric pentadecapeptide protecting gastrointestinal tract. significance of counteraction of vascular and multiorgan failure of occlusion/occlusion-like syndrome in cytoprotection/organoprotection
Since the early 1990s, when Robert’s and Szabo’s cytoprotection concept had already been more than one decade old, but still not implemented in...
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Protective effects of ginsenosides on ulcerative colitis: a meta-analysis and systematic review to reveal the mechanisms of action
BackgroundUlcerative colitis (UC) is a chronic inflammatory disease of the colon. Ginsenoside may be an ideal agent for UC treatment. However, its...
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The effect of SSRIs on unconditioned anxiety: a systematic review and meta-analysis of animal studies
RationaleSelective serotonin reuptake inhibitors (SSRIs) are the first choice of treatment for anxiety-like disorders. However, which aspects of...
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Androgen transition and management of hereditary angioedema long-term prophylaxis in real life: a single-center case series
BackgroundHereditary angioedema (HAE) is a rare and potentially life-threatening disease that manifests clinically as recurrent episodes of swelling...
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Generalized welfare lower bounds and strategyproofness in sequencing problems
In an environment with private information, we study the class of sequencing problems with welfare lower bounds. The “generalized welfare lower...
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Willingness to pay for chronic disease management services provided by primary care nurses
BackgroundDue to the rapid increase in chronic diseases in South Korea, the Korean government has expanded chronic disease management to primary...
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Impacts of X-linked Retinitis Pigmentosa and Patient Pathways in European Countries: Results from the Cross-sectional EXPLORE XLRP-1 Physician Survey
IntroductionX-linked retinitis pigmentosa (XLRP) is a rare, incurable, vision-threatening, genetic disease. In this study, we aimed to reveal the...
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Increased Risk of Severe Cardiovascular Events Following Exacerbations of Chronic Obstructive Pulmonary Disease: Results of the EXACOS-CV Study in Japan
IntroductionSevere exacerbations of chronic obstructive pulmonary disease (COPD) are known to increase the risk of cardiovascular events. However,...
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Usability of the SB11 Pre-filled Syringe (PFS) in Patients with Retinal Diseases
IntroductionSB11 (Byooviz™; Samsung Bioepis Co., Ltd.) is a ranibizumab (Lucentis ® ; Genentech, Inc.) biosimilar targeting vascular endothelial...
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ENTPD1 (CD39) and NT5E (CD73) expression in human medulloblastoma: an in silico analysis
Medulloblastoma is the most common malignant tumor in the pediatric population. Its classification has incorporated key molecular variations...
