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Insights into atypical segmental layer thicknesses and phase retardation in thick corneas using ultrahigh-resolution polarization-sensitive optical coherence tomography
BackgroundAccurately assessing corneal structural status is challenging when thickness deviates from the average. Polarization-sensitive optical...
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Infectious keratitis in pediatric population aged less than two years: a tertiary eye institute experience
BackgroundInfectious keratitis is a serious ocular condition, which can lead to corneal scarring, vision loss, and even blindness. Pediatric...
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Drug Interactions between Traditional Chinese Medicines and Cardiovascular Drugs
Cardiovascular disease (CVD) is one of the leading causes of death worldwide, and its internal medicine treatments are mostly single/few-target...
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Diagnosis of forme fruste keratoconus with scheimpflug photography in Ghanaian patients
AimThis study aimed to differentiate moderate to high myopic astigmatism from forme fruste keratoconus using Pentacam parameters and develop a...
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Inverted flap technique versus internal limiting membrane insertion for macular hole in eyes with extremely high myopia
BackgroundTo compare the surgical outcomes of the inverted internal limiting membrane (ILM) flap technique and ILM insertion for macular hole (MH)...
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A Short Game-Based Intervention for Enhancing Executive Functions at School: a Pilot Study
Executive functions (EFs) are crucial for self-regulation, and they can explain the difficulties that many children face at school in terms of both...
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Digital histology of retinal microaneurysms as provided by dense B-scan (DART) OCTA: characteristics and clinical relevance in diabetic retinopathy
BackgroundRetinal microaneurysms (MAs) are among the earliest signs of diabetic retinopathy (DR) and can be classified in several subtypes by...
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Impact of once-daily versus multiple-daily dosing of gentamicin on the incidence of acute kidney injury in patients treated with synergistic combinations of antibiotics
BackgroundGentamicin is a commonly used antibiotic with synergistic effects that is administered once or multiple times daily. However, the influence...
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Realizing time-staggered expression of nucleic acid-encoded proteins by co-delivery of messenger RNA and plasmid DNA on a single nanocarrier
Co-delivery of different protein-encoding polynucleotide species with varying expression kinetics of their therapeutic product will become a...
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Chemical engineering of zein with polyethylene glycol and Angiopep-2 to manufacture a brain-targeted docetaxel nanomedicine for glioblastoma treatment
Glioblastoma (GBM) is the deadliest adult brain cancer. The current standard-of-care chemotherapy using orally administered temozolomide (TMZ)...
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Biodynamers: applications of dynamic covalent chemistry in single-chain polymer nanoparticles
Dynamic Covalent Chemistry (DCC) enables the development of responsive molecular systems through the integration of reversible bonds at the molecular...
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Estimating the Trial-by-Trial Learning Curve in Perceptual Learning with Hierarchical Bayesian Modeling
The learning curve serves as a crucial metric for assessing human performance in perceptual learning. It may encompass various component processes,...
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Design and Validation of Novel Potential Antiperspirant Peptides Blocking M3-Gαq Sweat Signaling Cascade
Sweat production is vital for human survival as its evaporation eases heat dissipation. Nevertheless, excessive perspiration or hyperhidrosis causes...
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Phacoemulsification combined with Kahook Dual Blade Goniotomy versus with Trabectome in the treatment of open angle glaucoma
PurposeTo compare the surgical effectiveness and safety of phacoemulsification combined with KDB (Phaco-KDB) and with Trabectome (Phaco-Trabectome)...
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Amelioration of breast cancer therapies through normalization of tumor vessels and microenvironment: paradigm shift to improve drug perfusion and nanocarrier permeation
Breast cancer (BC) is the most commonly diagnosed cancer among women. Chemo-, immune- and photothermal therapies are employed to manage BC. However,...
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Measuring and Understanding Market Exclusivity Length for New Prescription Drugs in France, Australia, and the USA
BackgroundOriginator drug manufacturers use several strategies to delay generic competition in the USA, but it remains unclear whether this results...
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Natural compounds-based nanomedicines for cancer treatment: Future directions and challenges
Several efforts have been extensively accomplished for the amelioration of the cancer treatments using different types of new drugs and less...
