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Characterization of a missense variant in COG5 in a Tunisian patient with COG5-CDG syndrome and insights into the effect of non-synonymous variants on COG5 protein
The clinical diagnosis of patients with multisystem involvement including a pronounced neurologic damage is challenging. High-throughput sequencing...
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Ultrasound-responsive Bi2MoO6-MXene heterojunction as ferroptosis inducers for stimulating immunogenic cell death against ovarian cancer
BackgroundOvarian cancer (OC) has the highest fatality rate among all gynecological malignancies, necessitating the exploration of novel, efficient,...
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Comprehensive analysis of transcription factors involved in odontoblast differentiation mechanism
Primary cultured odontoblasts rapidly lose their tissue-specific phenotype. To identify transcription factors (TF) that are important for the...
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The mouse Social Frailty Index (mSFI): a novel behavioral assessment for impaired social functioning in aging mice
Various approaches exist to quantify the aging process and estimate biological age on an individual level. Frailty indices based on an age-related...
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Preparation and property of PVA-based colorful coating composite reinforced with silica aerogel particles filled by high-loaded flame retardant
Hydrophilic mesoporous silica aerogel particles were synthesized via self-assembly of amphiphilic polymer (Ph8-PEG6-PEOS) and its instantaneous...
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Microfluidic synthesis of alginate co-polymeric microgels for enhanced protein delivery applications
Alginate-based microcapsules are promising carriers for drugs and biomedical agents due to their biodegradability, biocompatible character, and easy...
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A comparative study on the effect of nano-additives on the performance and emissions of a diesel engine run on palm biodiesel
Rising energy requirements in conjunction with the diminishment of fossil fuels and an accelerated pace of fuel consumption, combined with the...
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An end-to-end approach for single-cell infrared absorption spectroscopy of bacterial inclusion bodies: from AFM-IR measurement to data interpretation of large sample sets
BackgroundInclusion bodies (IBs) are well-known subcellular structures in bacteria where protein aggregates are collected. Various methods have...
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The obesity-related mutation gene on nonalcoholic fatty liver disease
The prevalence of overweight and obesity is increasing, leading to metabolic-associated fatty liver disease (MAFLD) characterized by excessive...
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In silico-guided discovery and in vitro validation of novel sugar-tethered lysinated carbon nanotubes for targeted drug delivery of doxorubicin
ContextMultiwalled carbon nanotubes (MWCNTs) functionalized with lysine via 1,3-dipolar cycloaddition and conjugated to galactose or mannose are...
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Yoda1 pretreated BMSC derived exosomes accelerate osteogenesis by activating phospho-ErK signaling via Yoda1-mediated signal transmission
Segmental bone defects, arising from factors such as trauma, tumor resection, and congenital malformations, present significant clinical challenges...
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Graphene oxide electrodes enable electrical stimulation of distinct calcium signalling in brain astrocytes
Astrocytes are responsible for maintaining homoeostasis and cognitive functions through calcium signalling, a process that is altered in brain...
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Ultrafast Response and Threshold Adjustable Intelligent Thermoelectric Systems for Next-Generation Self-Powered Remote IoT Fire Warning
Fire warning is vital to human life, economy and ecology. However, the development of effective warning systems faces great challenges of fast...
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Green sonochemical synthesis of ZnCo2O4 decorated with carbon nanofibers for enhanced electrochemical detection of bisphenol A in food products
The facile sonochemical synthesis is reported of zinc cobalt oxide (ZnCo 2 O 4 ) composited with carbon nanofiber (CNF). Structural, chemical, and...
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Genomic variants associated with age at diagnosis of childhood-onset type 1 diabetes
Age at diagnosis (AAD) of Type 1 diabetes (T1D) is determined by the age at onset of the autoimmune attack and by the rate of beta cell destruction...
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Causal inference of the effect of blood proteome on the risk of head and neck cancer: two-sample Mendelian randomization
Early diagnosis of head and neck cancer can improve therapeutic outcomes but remains a challenge. The blood proteome can comprise a key source of...
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Defect-engineered chiral metal–organic frameworks
Chirality has an important impact on chemical and biological research, as most active substances are chiral. In recent decades, metal–organic...
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Understanding epitaxial growth of two-dimensional materials and their homostructures
The exceptional physical properties of two-dimensional (2D) van der Waals (vdW) materials have been extensively researched, driving advances in...
