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  1. The ethics of artificial intelligence systems in healthcare and medicine: from a local to a global perspective, and back

    Artificial intelligence systems (ai-systems) (e.g. machine learning, generative artificial intelligence), in healthcare and medicine, have been...

    Article Open access 06 July 2024
  2. Preliminary field validity of ActiGraph-based energy expenditure estimation in wheelchair users with spinal cord injury

    Study design

    Cross-sectional validation study.

    Objectives

    To develop a raw acceleration signal-based random forest (RF) model for predicting total...

    Zijian Huang, Akhila L. Veerubhotla, ... Dan Ding in Spinal Cord
    Article 06 July 2024
  3. ConKeD: multiview contrastive descriptor learning for keypoint-based retinal image registration

    Abstract

    Retinal image registration is of utmost importance due to its wide applications in medical practice. In this context, we propose ConKeD, a...

    David Rivas-Villar, Álvaro S. Hervella, ... Jorge Novo in Medical & Biological Engineering & Computing
    Article Open access 06 July 2024
  4. Sperm-Specific CatSper is Not Conserved in All Vertebrates and May Not be the Only Progesterone-Responsive Ion Channel Present in Sperm

    Progesterone (P4) acts as a key conserved signalling molecule in vertebrate reproduction. P4 is especially important for mature sperm physiology and...

    Nishant Kumar Dubey, Vikash Kumar, Chandan Goswami in The Journal of Membrane Biology
    Article Open access 06 July 2024
  5. Single-cell transcriptomic profiling of human pancreatic islets reveals genes responsive to glucose exposure over 24 h

    Aims/hypothesis

    Disruption of pancreatic islet function and glucose homeostasis can lead to the development of sustained hyperglycaemia, beta cell...

    Caleb M. Grenko, Henry J. Taylor, ... D. Leland Taylor in Diabetologia
    Article Open access 05 July 2024
  6. Trajectories of BMI before and after diagnosis of type 2 diabetes in a real-world population

    Aims/hypothesis

    Few studies have examined the clinical characteristics associated with changes in weight before and after diagnosis of type 2...

    Louise A. Donnelly, Rory J. McCrimmon, Ewan R. Pearson in Diabetologia
    Article Open access 05 July 2024
  7. Higher fibre and lower carbohydrate intake are associated with favourable CGM metrics in a cross-sectional cohort of 470 individuals with type 1 diabetes

    Aims/hypothesis

    The aim of this work was to investigate the association between macronutrient intakes and continuous glucose monitoring (CGM) metrics...

    Douwe F. de Wit, Coco M. Fuhri Snethlage, ... Nordin M. J. Hanssen in Diabetologia
    Article Open access 05 July 2024
  8. Multiple ultradian rhythms of metabolism, body temperature and activity in Djungarian hamsters

    Djungarian hamsters (Phodopus sungorus) living at constant 15 °C T a in short photoperiod (8:16 h L:D) showed pronounced ultradian rhythms (URs) of...

    Gerhard Heldmaier, Luzie Braulke, ... Thomas Ruf in Journal of Comparative Physiology B
    Article Open access 05 July 2024
  9. Persistent sodium currents in neurons: potential mechanisms and pharmacological blockers

    Persistent sodium current (I NaP ) is an important activity-dependent regulator of neuronal excitability. It is involved in a variety of physiological...

    Peter Müller, Andreas Draguhn, Alexei V. Egorov in Pflügers Archiv - European Journal of Physiology
    Article Open access 05 July 2024
  10. The use of transcutaneous electrical acupoint stimulation to reduce opioid consumption in patients undergoing off-pump CABG: a randomized controlled trial

    Background

    High doses of long-acting opioids were used to facilitate off-pump coronary artery bypass grafting procedure, which may result in...

    Hui Zhang, Lini Wang, ... Chong Lei in Perioperative Medicine
    Article Open access 05 July 2024
  11. Enhanced deep leaning model for detection and grading of lumbar disc herniation from MRI

    Lumbar disc herniation is one of the most prevalent orthopedic issues in clinical practice. The lumbar spine is a crucial joint for movement and...

    **anyin Duan, Hanlin **ong, ... Haotian Yu in Medical & Biological Engineering & Computing
    Article 05 July 2024
  12. Technology advances in diabetes pregnancy: right technology, right person, right time

    This review outlines some of the extraordinary recent advances in diabetes technology, which are transforming the management of type 1 diabetes...

    Anna McLean, Louise Maple-Brown, Helen R. Murphy in Diabetologia
    Article Open access 05 July 2024
  13. Impact of medical therapy for hormone-secreting Pituitary tumors on bone

    Purpose

    Bone health is often impaired in patients with hormone-secreting pituitary tumors. Since medical therapy is central to their care,...

    Pamela U. Freda in Pituitary
    Article 05 July 2024
  14. Pituitary surgery and COVID

    An effect of the COVID-19 pandemic was the disruption of healthcare systems, especially surgical services provided to the community. Pituitary...

    Ameen Farsakh, Sandra Li, ... Tony Goldschlager in Pituitary
    Article 05 July 2024
  15. tRNA-derived fragments in T lymphocyte–beta cell crosstalk and in type 1 diabetes pathogenesis in NOD mice

    Aims/hypothesis

    tRNAs play a central role in protein synthesis. Besides this canonical function, they were recently found to generate non-coding RNA...

    Flora Brozzi, Cécile Jacovetti, ... Romano Regazzi in Diabetologia
    Article Open access 05 July 2024
  16. Impact of high-altitude hypoxia on Helicobacter pylori-induced gastritis pathological manifestations and inflammatory responses

    Background

    Chronic gastritis caused by Helicobacter pylori (Hp) infection is a common gastrointestinal disorder. Despite the high prevalence of Hp...

    Chunxia Li, Xuehong Wang, Sen Cui in Journal of Physiological Anthropology
    Article Open access 05 July 2024
  17. N-Glycosylation Deficiency in Transgene α7 nAChR and RIC3 Expressing CHO Cells Without NACHO

    The human neuronal nicotinic acetylcholine receptor α7 (nAChR) is an important target implicated in diseases like Alzheimer’s or Parkinson’s, as well...

    Sabrina Brockmöller, Lara Maria Molitor, ... Simone Rothmiller in The Journal of Membrane Biology
    Article 05 July 2024
  18. Temporal and masseter muscle evaluation by MRI provides information on muscle mass and quality in acromegaly patients

    Purpose

    The impact of GH/IGF-1 levels on skeletal muscle in acromegaly is still controversial. Temporal (TMT) and masseter muscle (MMT) thickness has...

    Federico Gatto, Angelo Milioto, ... Alberto Stefano Tagliafico in Pituitary
    Article Open access 05 July 2024
  19. Stretching intervention can prevent muscle injuries: a systematic review and meta-analysis

    Purpose

    Previous meta-analysis studies concluded that static stretching intervention cannot decrease all-cause injury in healthy active individuals....

    Kosuke Takeuchi, Masatoshi Nakamura, ... Takamasa Mizuno in Sport Sciences for Health
    Article 04 July 2024
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