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Delineating the response of antioxidant enzymes comparatively in four guar genotypes under drought stress
Antioxidant responses play a crucial role in combating free radical damage induced by drought stress. In guar plants, the antioxidant mechanism is...
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Exploring the variation in α-amylase activity and thermostability in green malt of diverse barley (Hordeum vulgare L.) germplasm
This study investigated the activity and thermostability of α-amylase in green malt across a diverse panel of 54 barley genotypes, comprising 20...
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Ikaros sets the threshold for negative B-cell selection by regulation of the signaling strength of the AKT pathway
Inhibitory phosphatases, such as the inositol-5-phosphatase SHIP1 could potentially contribute to B-cell acute lymphoblastic leukemia (B-ALL) by...
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Uncovering the role of ferroptosis in Bietti crystalline dystrophy and potential therapeutic strategies
PurposeBietti crystalline dystrophy (BCD) is an inherited retinal degeneration disease caused by mutations in the CYP4V2 gene. Currently, there is...
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Neutralizing antibody responses assessment after vaccination in people living with HIV using a surrogate neutralization assay
ObjectiveHIV has been reported to interfere with protective vaccination against multiple pathogens, usually through the decreased effectiveness of...
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Role of O-linked N-acetylglucosamine protein modification in oxidative stress-induced autophagy: a novel target for bone remodeling
O-linked N-acetylglucosamine protein modification (O-GlcNAcylation) is a dynamic post-translational modification (PTM) involving the covalent binding...
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Evaluation of immunophenotypic alterations of peripheral blood lymphocytes and their sub-sets in uncomplicated P. Falciparum infection
BackgroundMalaria is a life-threatening parasitic disease typically transmitted through the bite of an infected Anopheles mosquito. There is ample...
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Macrophage-derived exosomes promote telomere fragility and senescence in tubular epithelial cells by delivering miR-155
BackgroundChronic kidney disease (CKD) is highly prevalent worldwide, and its global burden is substantial and growing. CKD displays a number of...
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Emodin alleviates intestinal ischemia–reperfusion injury through antioxidant stress, anti-inflammatory responses and anti-apoptosis effects via Akt-mediated HO-1 upregulation
BackgroundIntestinal ischemia–reperfusion (I/R) injury is a severe vascular emergency. Previous research indicated the protective effects of Emodin...
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Hypoxic extracellular vesicles from hiPSCs protect cardiomyocytes from oxidative damage by transferring antioxidant proteins and enhancing Akt/Erk/NRF2 signaling
BackgroundStem cell-derived extracellular vesicles (EVs) are an emerging class of therapeutics with excellent biocompatibility, bioactivity and...
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Protective and curative effects of unconjugated bilirubin on gene expression of LOX-1 and iNOS in the heart of rats receiving high-fat diet and low dose streptozotocin: a histomorphometric approach
BackgroundAtherosclerosis is a chronic inflammatory condition affecting the large arteries and is a major cause of cardiovascular diseases (CVDs)...
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Gut microbiota regulation of T lymphocyte subsets during systemic lupus erythematosus
BackgroundSystemic lupus erythematosus (SLE) is an autoimmune disease characterized by disturbance of pro-inflammatory and anti-inflammatory...
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Ningetinib, a novel FLT3 inhibitor, overcomes secondary drug resistance in acute myeloid leukemia
BackgroundFMS-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is a common mutation type in acute myeloid leukemia (AML) and is usually...
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LCP1 correlates with immune infiltration: a prognostic marker for triple-negative breast cancer
ObjectiveTriple-Negative Breast Cancer (TNBC) is known for its aggressiveness and treatment challenges due to the absence of ER, PR, and HER2...
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tRF-His-GTG-1 enhances NETs formation and interferon-α production in lupus by extracellular vesicle
BackgroundHyperactive neutrophil extracellular traps (NETs) formation plays a crucial role in active severe systemic lupus erythematosus (SLE)....
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The ethics of artificial intelligence systems in healthcare and medicine: from a local to a global perspective, and back
Artificial intelligence systems (ai-systems) (e.g. machine learning, generative artificial intelligence), in healthcare and medicine, have been...
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Persistent sodium currents in neurons: potential mechanisms and pharmacological blockers
Persistent sodium current (I NaP ) is an important activity-dependent regulator of neuronal excitability. It is involved in a variety of physiological...
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The crosstalk between copper-induced oxidative stress and cuproptosis: a novel potential anticancer paradigm
Copper is a crucial trace element that plays a role in various pathophysiological processes in the human body. Copper also acts as a transition metal...
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Hainanenin-1, an oncolytic peptide, triggers immunogenic cell death via STING activation in triple-negative breast cancer
BackgroundIn triple-negative breast cancer (TNBC) therapy, insufficient tumor infiltration by lymphocytes significantly hinders the efficacy of...
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Overexpression of the MiAGL1 gene from mango promoted flowering in transgenic Arabidopsis
MADS-box genes play a vital role in the vegetative and reproductive growth of plants. In this study, a MiAGL1 gene was cloned and identified from...
