Search
Search Results
-
Enteroviruses: epidemic potential, challenges and opportunities with vaccines
Enteroviruses (EVs) are the most prevalent viruses in humans. EVs can cause a range of acute symptoms, from mild common colds to severe systemic...
-
Heterotrimeric collagen helix with high specificity of assembly results in a rapid rate of folding
The most abundant natural collagens form heterotrimeric triple helices. Synthetic mimics of collagen heterotrimers have been found to fold slowly,...
-
Isolation and characterization of a two-coordinate phosphinidene oxide
Nitroso compounds, R–N=O, are common intermediates in organic synthesis, and are typically amenable to storage and manipulation at ambient...
-
-
Outpatient reception via collaboration between nurses and a large language model: a randomized controlled trial
Reception is an essential process for patients seeking medical care and a critical component influencing the healthcare experience. However, current...
-
Prompt closure versus gradual weaning of external ventricular drain for hydrocephalus following aneurysmal subarachnoid haemorrhage: a statistical analysis plan for the DRAIN randomised clinical trial
BackgroundInsertion of an external ventricular drain (EVD) is a first-line treatment of acute hydrocephalus caused by aneurysmal subarachnoid...
-
Panoramic tumor microenvironment in pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is notorious for its resistance to various treatment modalities. The genetic heterogeneity of PDAC, coupled...
-
Cerium oxide nanofibers via electrospinning: a potential material to purge waterways of chemical pollutants and foodborne pathogens
Food is frequently contaminated by foodborne pathogens, predominantly bacteria and fungi but occasionally certain viruses as well as protozoa during...
-
Lessons from the physiological role of guanosine in neurodegeneration and cancer: Toward a multimodal mechanism of action?
Neurodegenerative diseases and brain tumours represent important health challenges due to their severe nature and debilitating consequences that...
-
Tumoral periprostatic adipose tissue exovesicles-derived miR-20a-5p regulates prostate cancer cell proliferation and inflammation through the RORA gene
BackgroundFrom the first steps of prostate cancer (PCa) initiation, tumours are in contact with the most-proximal adipose tissue called periprostatic...
-
Prenatal affective cognitive training to reduce the risk of postpartum depression (PACT): study protocol for a randomized controlled trial
BackgroundPostpartum depression (PPD) affects 30–50% of women with a history of previous depression or bipolar disorder and 8% of women with no...
-
Short-term S100A8/A9 Blockade Promotes Cardiac Neovascularization after Myocardial Infarction
Acute-phase inhibition of the pro-inflammatory alarmin S100A8/A9 improves cardiac function post-myocardial infarction (MI), but the mechanisms...
-
DAP12 interacts with RER1 and is retained in the secretory pathway before assembly with TREM2
DNAX-activating protein of 12 kDa (DAP12) is a transmembrane adapter protein expressed in lymphoid and myeloid lineage cells. It interacts with...
-
How bile acids and the microbiota interact to shape host immunity
Bile acids are increasingly appearing in the spotlight owing to their novel impacts on various host processes. Similarly, there is growing attention...
-
In-vitro and in-silico evaluation of anticancer potential of Oxalis corniculata
Plant secondary metabolites have been gaining significant attention as potential cancer therapeutics in recent years. In several cases, these are...
-
-
The BCR::ABL1 tyrosine kinase inhibitors ponatinib and nilotinib differentially affect endothelial angiogenesis and signalling
BCR::ABL1 inhibitors, the treatment of choice for the majority of patients with chronic myeloid leukaemia (CML), can cause vascular side effects that...
-
Effect of Physicochemical Properties on the Basic Drug-Acid-Polymer Interactions and Miscibility in PVA Based Orodispersible Films
Salts of weakly basic drugs can partially dissociate in formulations, to give basic drugs and counter acids. The aim of the present study was to...
-
Important role of Bacillus subtilis as a probiotic and vaccine carrier in animal health maintenance
Bacillus subtilis is a widespread Gram-positive facultative aerobic bacterium that is recognized as generally safe. It has shown significant...
