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Determination of bisphosphonate properties in terms of bioavailability, bone affinity, and cytotoxicity
BackgroundThe study aimed to evaluate the therapeutic potential of fourteen newly synthesized bisphosphonates by assessing their bioavailability,...
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Mitochondrial targeted antioxidants as potential therapy for huntington’s disease
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by an expansion in CAG repeat on huntington (Htt) gene, leading to a...
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Insulin resistance, clinical presentation and resistance to selective serotonin and noradrenaline reuptake inhibitors in major depressive disorder
BackgroundThe understanding of mechanisms underlying non-response to antidepressants is limited. The latest data highlights the role of insulin...
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Uncovering the unique characteristics of different groups of 5-HT5AR ligands with reference to their interaction with the target protein
BackgroundThe serotonin 5-HT 5A receptor has attracted much more research attention, due to the therapeutic potential of its ligands being...
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Advances in the anti-tumor mechanisms of saikosaponin D
Saikosaponin D, a saponin compound, is extracted from Bupleurum and is a principal active component of the plant. It boasts a variety of...
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Efficiency of eSource Direct Data Capture in Investigator-Initiated Clinical Trials in Oncology
BackgroundClinical trials have become larger and more complex. Thus, eSource should be used to enhance efficiency. This study aimed to evaluate the...
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Research progress of propofol in alleviating cerebral ischemia/reperfusion injury
Ischemic stroke is a leading cause of adult disability and death worldwide. The primary treatment for cerebral ischemia patients is to restore blood...
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Mutagenic Azido Impurities in Drug Substances: A Perspective
Contamination of drug products and substances containing impurities is a significant concern in the pharmaceutical industry because it may impact the...
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Can probiotics be used in the prevention and treatment of bronchial asthma?
Asthma is a lifelong condition with varying degrees of severity and susceptibility to symptom control. Recent studies have examined the effects of...
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Interactions between metabotropic glutamate and CB1 receptors: implications for mood, cognition, and synaptic signaling based on data from mGluR and CB1R-targeting drugs
Metabotropic glutamate receptors (mGluRs) are part of the G protein-coupled receptors (GPCRs) family. They are coupled to G αq (group I) or G i/o ...
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Mechanistic insights on TLR-4 mediated inflammatory pathway in neurodegenerative diseases
Neurodegenerative diseases (NDDs) pose a significant issue in healthcare, needing a thorough knowledge of their complex molecular mechanisms. A...
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A derivative of 3-(1,3-diarylallylidene)oxindoles inhibits dextran sulfate sodium-induced colitis in mice
BackgroundIA-0130 is a derivative of 3-(1,3-diarylallylidene)oxindoles, which is a selective estrogen receptor modulator (SERM). A previous study...
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Qualitative Analysis of Inquiries Received by FDA Regarding Conduct of Clinical Trials during the Covid-19 Public Health Emergency
BackgroundThis report describes the U.S. Food and Drug Administration (FDA) experience in establishing a dedicated mailbox, and in publishing related...
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Multi-layered metabolic effects of trehalose on the liver proteome in apoE-knockout mice model of liver steatosis
BackgroundMetabolic dysfunction-associated fatty liver disease has been well documented as a key independent risk factor for the development of...
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Use of Seamless Study Designs in Oncology Clinical Development– A Survey Conducted by IDSWG Oncology Sub-team
Seamless study designs have the potential to accelerate clinical development. The use of innovative seamless designs has been increasing in the...
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Patient and Public Perceptions in Canada About Decentralized and Hybrid Clinical Trials: “It’s About Time we Bring Trials to People”
BackgroundLittle is known about patient and the public perspectives on decentralized and hybrid clinical trials in Canada.
MethodsWe conducted an...
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Luteolin for neurodegenerative diseases: a review
Neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and multiple sclerosis affect millions of people...
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The effect of phencyclidine-mediated blockade of NMDA receptors in the early postnatal period on glutathione and sulfur amino acid levels in the rat brain as a potential causative factor of schizophrenia-like behavior in adulthood
BackgroundPhencyclidine, an NMDA receptor antagonist, is frequently used to model behavioral and neurochemical changes correlated with schizophrenia...
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Harmonizing Quality Improvement Metrics Across Global Trial Networks to Advance Paediatric Clinical Trials Delivery
BackgroundDespite global efforts to improve paediatric clinical trials, significant delays continue in paediatric drug approvals. Collaboration...
