Search
Search Results
-
Review of the Modern Market of Reagents for the Detection of Bacterial Endotoxins in Drugs
A comparative study of reagents obtained from hemolymph of Atlantic and Asian horseshoe crabs proved the reliability of bacterial endotoxin...
-
Chemical Compositions and Pharmacological Activities of Iberis amara L. (A Review)
Iberis amara L. belongs to the family of Brassicaceae, which is native to Southern Europe. It is a bloomer cultivated as an ornamental and medicinal...
-
Variability of the Constituent Composition of Mentha piperita L. Essential Oil
Varieties of Mentha piperita L. (peppermint) cultivated at altitudes of 1100 and 1650 m above sea level on identical soils were studied to identify...
-
Study of Impurity Profiles in Raw Materials and Tablets of Rutin and Its Production Process: Correlation Analysis
An HPLC-UV method with high sensitivity and good resolution, calculated by the principal component external standard method with correction factors...
-
Analytical Quality by Design Approach for the Development and Validation of Liquid Chromatographic Procedure for the Estimation of Abrocitinib
Analytical quality by design-based HPLC procedure has been developed for the estimation of Abrocitinib in bulk and tablets. Design-Expert ® -13 was...
-
Cryptotanshinone Inhibits the Proliferation of 5-Fluorouracil-Resistant Gastric Cancer SGC-7901/5-FU Cells Via the JAK2/STAT3 Pathway
Cryptotanshinone (CPT), which is an important active ingredient of herbs, has shown great value for research. In particular, CPT exerts antitumor...
-
Cytotoxic and Apoptosis-Inducing Activities of Iridium Complexes Bearing 2-Phenylimidazo[4,5-f][1,10]-Phenanthroline Derivatives in Human Cancer Cells
In recent years, there has been growing exploration of organometallic transition metal complexes as promising options for develo** anticancer...
-
Dimethyl Fumarate Ameliorates the Amyotrophic Lateral Sclerosis Symptoms in Tg-SOD1G93A Mice
Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disorder that affects motor neurons and has limited therapeutic...
-
Study of pH-Dependent Kinetics of Filgrastim Pegylation with Succinimide Derivatives of Poly(Ethylene Glycol) and Comparison of the Properties of Pegylated Forms Obtained Under Various Conditions
Filgrastim was pegylated by acylation with a linear 20-kDa pegylating agent (PEG agent) to search for conjugates characterized by biological activity...
-
Synthesis of New Conjugates of Edaravone and 1-Aminoadamantanes and Their Interaction with NMDA Receptors in Rats
New adamantane-containing derivatives of edaravone, one of two drugs used to treat amyotrophic lateral sclerosis, were synthesized. The pyrazolone...
-
Application of Response Surface Methodology for the Development of an Innovative Stability-Indicating UHPLC Method for the Simultaneous Determination of Embelin and Vilangin in Vidanga (Embelia ribes) Tablets
The current study highlights the systematic quality by design-assisted creation of an efficient analytical technique for the estimation of embelin...
-
Therapeutic Potential of Pyrazole Containing Compounds: an Updated Review
Among a large number of nitrogen-containing heterocyclic compounds, pyrazole is a privileged scaffold with the molecular formula C 3 H 3 N 2 H. It consists...
-
Synthesis, Molecular Modeling and Biological Assessment of Aryloxymethyl 1,3,4-Thiadiazole and 1,2,4-Triazole-5-Thione Derivatives as Potential Cox Inhibitors
Thiadiazole and triazole-5-thione derivatives are five membered heterocyclic compounds showing cyclooxygenase inhibition activities. Based on this...
-
Resveratrol, Tyrosol and Their Derivatives Inhibit Platelet Activating Factor Biosynthetic Enzymes in Homogenized U-937 Cells
Platelet activating factor (PAF) is a potent lipid mediator involved in inflammation, among other pathophysiological conditions. Bioactive compounds...
-
Hot Melt Extrusion Technology as a Modern Strategy for Improving the Bioavailability of Flavonoids
The pharmacological activity of flavonoids as potential candidates for the development of drugs based on biologically active substances of plant...
-
Synthesis and Biological Evaluation of Arctigenin-Dipeptide Derivatives as Potential Anti-Fatigue Agents
Fatigue is a physiological phenomenon experienced by the human body when it undergoes prolonged physical and mental exertion, which can have...
-
Toxicity and Antihypoxic Activity of a Preparation Containing a Complex Compound of 5-Hydroxy-6-Methyluracil with N-Acetyl Cysteine
5-Hydroxy-6-methyluracil (5-OH-6-MU) was shown to form a 1:1 complex with N -acetylcysteine (N-AC), i.e., the compounds interacted in an equimolar...
-
The Role of Lycium barbarum (Goji Berry) in Apoptosis and Autophagy in the Experimental Ulcerative Colitis Model
Ulcerative colitis is one of the most common intestinal diseases in the world. Lycium barbarum (Goji Berry) is a type of fruit that is frequently...
-
Effect of Quercetin and its Derivatives on the Excretory Function of Rat Kidneys
The optimal diuretic doses of quercetin and rutin (5 mg/kg) and dihydroquercetin and hyperoside (1 mg/kg) were determined in experiments on white...
-
E1231 Alleviates Diabetic Cardiomyopathy by Regulating the Silent Information Regulator 1/Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α/Nuclear Factor Erythroid 2-Related Factor 2 Pathway
We aimed to investigate the underlying function and mechanism of E1231 against diabetic cardiomyopathy (DCM). H9c2 cells were exposed to either 33...
