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Altered RNA export by SF3B1 mutants confers sensitivity to nuclear export inhibition
SF3B1 mutations frequently occur in cancer yet lack targeted therapies. Clinical trials of XPO1 inhibitors, selinexor and eltanexor, in high-risk...
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Predictive enrichment for the need of renal replacement in sepsis-associated acute kidney injury: combination of furosemide stress test and urinary biomarkers TIMP-2 and IGFBP-7
BackgroundIn sepsis, initial resuscitation with fluids is followed by efforts to achieve a negative fluid balance. However, patients with...
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Magnitude of emergence agitation, its interventions and associated factors among paediatric surgical patients
BackgroundEmergence agitation is a transient confusional state of a child associated with consciousness from general anaesthesia, commonly occurs in...
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Beneficial Effect of Pretreatment Hyperosmolality on Outcome in Severe Traumatic Brain Injury: Evidence from a South Korean Multicenter Registry and Propensity Score Matching Analysis
BackgroundHyperosmolar therapy has long been a cornerstone in managing increased intracranial pressure and improving outcomes in severe traumatic...
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The role of upper airway ultrasonography in tracheal necrosis diagnosis: a case report
BackgroundTracheal necrosis post endotracheal intubation is a rare life-threatening disease that can compromise airway patency. We demonstrated a...
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An elderly case of paraneoplastic anti-NMDA receptor encephalitis associated with large cell neuroendocrine carcinoma of the lung
BackgroundRecent studies have suggested that N-methyl-D-aspartate (NMDA) receptors are involved in the cell proliferation in several tumors. However,...
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Trace of delirium after robotic lower abdominal tumor resection at different end-tidal carbon dioxide: a RCT trial
BackgroundPostoperative delirium (POD) often occurs in oncology patients, further increasing the medical and financial burden. Robotic technology in...
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Prognostic value of serial (1,3)-β-d-glucan measurements in ICU patients with invasive candidiasis
BackgroundTo determine whether a decrease in serum (1,3)-β- d -glucan (BDG) was associated with reduced mortality and to investigate the performance...
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3D C-arm navigated suture button implantation for AC joint dislocations - the pilot study
PurposeThe surgical treatment of acute traumatic AC joint dislocations is still a subject of scientific debate in the literature. The...
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Good outcome with conservative treatment of delayed spinal epidural hematoma following combined spinal-epidural anesthesia: a rare case report
BackgroundDelayed spinal epidural hematoma (SEH) following central neuraxial block (CNB) is a rare but serious complication. The underlying causes of...
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Efficacy and Safety of Atogepant for Preventing Chronic and Episodic Migraines: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Purpose of ReviewCalcitonin gene-related peptide (CGRP) pathway modulators, such as atogepant, represent a novel therapeutic option for the treatment...
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Resilience after severe critical illness: a prospective, multicentre, observational study (RESIREA)
BackgroundCritical-illness survivors may experience post-traumatic stress disorder (PTSD) and quality-of-life impairments. Resilience may protect...
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Longitudinal lung function trajectories in response to azithromycin therapy for chronic lung disease in children with HIV infection: a secondary analysis of the BREATHE trial
BackgroundChronic lung disease (CLD) is common among children with HIV (CWH) including in those taking antiretroviral therapy (ART). Azithromycin has...
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Differentiating rhythmic high-amplitude delta with superimposed (poly) spikes from extreme delta brushes: limitations of standardized nomenclature and implications for patient management
BackgroundFollowing the standardized nomenclature proposed by the American Clinical Neurophysiology Society (ACNS), rhythmic high-amplitude delta...
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Optimization of kidney function in cardiac surgery patients with intra-abdominal hypertension: expert opinion
Cardiac surgery-associated acute kidney injury (CSA-AKI) affects up to 42% of cardiac surgery patients. CSA-AKI is multifactorial, with low abdominal...
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Metagenomic next-generation sequencing promotes diagnosis and treatment of Pneumocystis jirovecii pneumonia in non-HIV infected children: a retrospective study
BackgroundMetagenomic next-generation sequencing (mNGS) excels in diagnosis of infection pathogens. We aimed to evaluate the performance of mNGS for...
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BART, the new robotic assistant: big data, artificial intelligence, robotics, and telemedicine integration for an ICU 4.0
We are in the era of Health 4.0 when novel technologies are providing tools capable of improving the quality and safety of the services provided. Our...
