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Midregional Proatrial Natriuretic Peptide (MRproANP) is associated with vertebral fractures and low bone density in patients with chronic obstructive pulmonary disease (COPD)
BackgroundPatients with COPD are often affected by loss of bone mineral density (BMD) and osteoporotic fractures. Natriuretic peptides (NP) are known...
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The evolving landscape of IL-10, IL-22 and IL-26 in pleurisy especially in tuberculous pleurisy
Pleurisy can be categorized as primary or secondary, arising from immunological, tumorous, or microbial conditions. It often results in lung...
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An elderly case of paraneoplastic anti-NMDA receptor encephalitis associated with large cell neuroendocrine carcinoma of the lung
BackgroundRecent studies have suggested that N-methyl-D-aspartate (NMDA) receptors are involved in the cell proliferation in several tumors. However,...
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Transcriptomic Expression of T2-Inflammation Genes in Peripheral Blood Mononuclear Cells and Longitudinal Clinical Outcomes in Asthma: Insights from the COREA Study
BackgroundGene expression can provide distinct information compared to clinical biomarkers in the context of longitudinal clinical outcomes in asthma...
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Novel physiologic predictors of positive airway pressure effectiveness (NICEPAP) study: rationale, design and methods
PurposeContinuous positive airway pressure (CPAP) is the primary therapy for obstructive sleep apnea (OSA); however the effectiveness of CPAP remains...
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Longitudinal lung function trajectories in response to azithromycin therapy for chronic lung disease in children with HIV infection: a secondary analysis of the BREATHE trial
BackgroundChronic lung disease (CLD) is common among children with HIV (CWH) including in those taking antiretroviral therapy (ART). Azithromycin has...
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Performing polysomnography in pre-school aged children: challenging parts of the procedure and risk factors for lead intolerance
PurposePediatric sleep apnea begins in toddlerhood when sleep is vital for neurocognitive development and rapid somatic growth. As polysomnography...
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Metagenomic next-generation sequencing promotes diagnosis and treatment of Pneumocystis jirovecii pneumonia in non-HIV infected children: a retrospective study
BackgroundMetagenomic next-generation sequencing (mNGS) excels in diagnosis of infection pathogens. We aimed to evaluate the performance of mNGS for...
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The integrin receptor beta7 subunit mediates airway remodeling and hyperresponsiveness in allergen exposed mice
BackgroundFibroblast differentiation to a myofibroblast phenotype is a feature of airway remodeling in asthma. Lung fibroblasts express the integrin...
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The utility of various predictive equations in patients with severe Obstructive Sleep Apnea: a clinical practice viewpoint in settings with limited resources
BackgroundThe continuous positive airway pressure (CPAP) needed for the treatment of obstructive sleep apnea (OSA) can be determined after a manual...
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The Effect of Long-Term Azithromycin on Objective and Subjective Cough in Chronic Respiratory Disease: A Systematic Review and Meta-analysis of Randomised Controlled Trials and Noncomparative Studies
IntroductionAzithromycin is an effective treatment for various respiratory conditions but its effect on cough is poorly understood. We synthesised...
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Childhood asthma and mould in homes—A meta-analysis
Asthma is a multifaceted and multicausal disease. Childhood asthma is strongly influenced by genetic traits and is characterized by hyperreactivity...
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Lower or higher oxygenation targets in the intensive care unit: an individual patient data meta-analysis
PurposeOptimal oxygenation targets for patients with acute hypoxemic respiratory failure in the intensive care unit (ICU) are not clearly defined due...
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Physiologic and anatomic determinants of hyoid motion during drug-induced sleep endoscopy
PurposeTo examine factors accounting for differences in hyoid motion during obstructive breathing events amongst obstructive sleep apnea (OSA)...
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Tezepelumab for refractory eosinophilic granulomatosis with polyangiitis-related asthma
Conventional immunosuppressants are ineffective for the management of EGPA-related asthma. Tezepelumab is a human monoclonal antibody that inhibits...
