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SUMOylation of nuclear receptor Nor1/NR4A3 coordinates microtubule cytoskeletal dynamics and stability in neuronal cells
BackgroundNor1/NR4A3 is a member of the NR4A subfamily of nuclear receptors that play essential roles in regulating gene expression related to...
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Effects of warm oceanographic anomalies on the foraging variability of northern elephant seals
Evaluation of stable carbon (δ 13 C) and nitrogen (δ 15 N) isotopes in marine organisms over time addresses how environmental variability (e.g., El...
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Identification of volatile metabolites produced from levodopa metabolism by different bacteria strains of the gut microbiome
Interspecies pathways in the gut microbiome have been shown to metabolize levodopa, the primary treatment for Parkinson’s disease, and reduce its...
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C4-like Sesuvium sesuvioides (Aizoaceae) exhibits CAM in cotyledons and putative C4-like + CAM metabolism in adult leaves as revealed by transcriptome analysis
BackgroundThe co-occurrence of C 4 and CAM photosynthesis in a single species seems to be unusual and rare. This is likely due to the difficulty in...
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Production of a bacterial secretome highly efficient for the deconstruction of xylans
Bacteria within the Paenibacillus genus are known to secrete a diverse array of enzymes capable of breaking down plant cell wall polysaccharides. We...
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Bacillus amyloliquefaciens Protect Against Atherosclerosis Through Alleviating Foam Cell Formation and Macrophage Polarization
This study was to investigate the therapeutic effect of Bacillus amyloliquefaciens (Ba) on atherosclerosis (AS). THP-1 monocyte was differentiated to...
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GPR116 alleviates acetaminophen-induced liver injury in mice by inhibiting endoplasmic reticulum stress
BackgroundAcetaminophen (APAP) overdose is a significant contributor to drug-induced liver injury worldwide. G-protein–coupled receptor 116 (GPR116)...
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IL-4/IL-4R axis signaling drives resistance to immunotherapy by inducing the upregulation of Fcγ receptor IIB in M2 macrophages
In recent years, immunotherapy, particularly PD-1 antibodies, have significantly enhanced the outcome of gastric cancer patients. Despite these...
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Biochemical characterisation and production kinetics of high molecular-weight (HMW) putative antibacterial proteins of insect pathogenic Brevibacillus laterosporus isolates
BackgroundBacterial genomes often encode structures similar to phage capsids (encapsulins) and phage tails which can be induced spontaneously or...
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Deep metagenomic sequencing unveils novel SAR202 lineages and their vertical adaptation in the ocean
SAR202 bacteria in the Chloroflexota phylum are abundant and widely distributed in the ocean. Their genome coding capacities indicate their potential...
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Delineating the response of antioxidant enzymes comparatively in four guar genotypes under drought stress
Antioxidant responses play a crucial role in combating free radical damage induced by drought stress. In guar plants, the antioxidant mechanism is...
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The excito-repellent activity of five essential oils extracted from local plants against dengue and malaria vectors in Burkina Faso
Using chemical insecticides remains the main way to prevent and manage dengue and malaria, two main mosquito-borne diseases. However, the vectors of...
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First Report of Bothynus striatellus (Coleoptera: Melolonthidae) Damaging Lucerne Crops in Argentina
We report for the first time that larvae of the genus Bothynus Hope (Coleoptera: Melolonthidae) caused economic damage to lucerne ( Medicago sativa ...
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Exploring the influence of rapeseed cultivar and pathogen isolate on Acremonium alternatum's efficacy in clubroot disease control
Clubroot disease, caused by Plasmodiophora brassicae , ranks among the most significant diseases affecting rapeseed cultivars, leading to substantial...
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Distinct dynamic connectivity profiles promote enhanced conscious perception of auditory stimuli
The neuroscience of consciousness aims to identify neural markers that distinguish brain dynamics in healthy individuals from those in unconscious...
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Astrocytes enhance plasticity response during reversal learning
Astrocytes play a key role in the regulation of synaptic strength and are thought to orchestrate synaptic plasticity and memory. Yet, how...
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An altered uterine microbiota with endometrial hyperplasia
BackgroundEndometrial hyperplasia (EH) is a precursor to endometrial cancer, and the role of the microbiome in its development is unclear.
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KKL-35 inhibits growth of Staphylococcus aureus by systematically changing bacterial phenotypes
KKL-35 is a new oxadiazole compound with potent broad-spectrum antibacterial activity against a number of gram-positive and gram-negative bacteria....