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Reward system activation improves recovery from acute myocardial infarction
Psychological processes have a crucial role in the recovery from acute myocardial infarction (AMI), yet the underlying mechanisms of these effects...
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Reversal of pulmonary veno-occlusive disease phenotypes by inhibition of the integrated stress response
Pulmonary veno-occlusive disease (PVOD) is a rare form of pulmonary hypertension arising from EIF2AK4 gene mutations or mitomycin C (MMC)...
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A KLF2-BMPER-Smad1/5 checkpoint regulates high fluid shear stress-mediated artery remodeling
Vascular remodeling to match arterial diameter to tissue requirements commonly fails in ischemic disease. Endothelial cells sense fluid shear stress...
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Nuclear ATP-citrate lyase regulates chromatin-dependent activation and maintenance of the myofibroblast gene program
Differentiation of cardiac fibroblasts to myofibroblasts is necessary for matrix remodeling and fibrosis in heart failure. We previously reported...
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A common gene signature of the right ventricle in failing rat and human hearts
The molecular mechanisms of progressive right heart failure are incompletely understood. In this study, we systematically examined transcriptomic...
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Multi-expert ensemble ECG diagnostic algorithm using mutually exclusive–symbiotic correlation between 254 hierarchical multiple labels
Electrocardiograms (ECGs) are a cheap and convenient means of assessing heart health and provide an important basis for diagnosis and treatment by...
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Management and prevention of in-hospital cardiac arrest: present and future
Cardiac arrest is most commonly defined as the cessation of cardiac mechanical activity requiring either delivery of chest compressions and/or...
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Assessing the arrhythmogenic propensity of fibrotic substrate using digital twins to inform a mechanisms-based atrial fibrillation ablation strategy
Atrial fibrillation (AF), the most common heart rhythm disorder, may cause stroke and heart failure. For patients with persistent AF with fibrosis...
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Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease
Major depressive disorder (MDD) and cardiovascular disease (CVD) are often comorbid, resulting in excess morbidity and mortality. Here we show that...
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Egr1 regulates regenerative senescence and cardiac repair
Senescence plays a key role in various physiological and pathological processes. We reported that injury-induced transient senescence correlates with...
