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Herbidomicins, two pairs of polyketide tautomers produced by an actinomycete of the genus Herbidospora
Herbidospora is one of the underexplored actinomycete genera from which only a limited number of secondary metabolites are reported. In our...
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Pharmacological Doses of Thiamine Benefit Patients with the Charcot–Marie–Tooth Neuropathy by Changing Thiamine Diphosphate Levels and Affecting Regulation of Thiamine-Dependent Enzymes
AbstractCharcot–Marie–Tooth (CMT) neuropathy is a polygenic disorder of peripheral nerves with no effective cure. Thiamine (vitamin B1) is a...
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Repurposing of dibucaine and niflumic acid as antimicrobial agents in combination with antibiotics against Staphylococcus aureus
The versatile human commensal bacteria and pathogen Staphylococcus aureus cause several community and hospital-acquired illnesses associated with...
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Hibiscus acid and hydroxycitric acid dimethyl esters from Hibiscus flowers induce production of dithiolopyrrolone antibiotics by Streptomyces Strain MBN2-2
Plants and microbes are closely associated with each other in their ecological niches. Much has been studied about plant–microbe interactions, but...
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Revealing the effect of sea buckthorn oil, fish oil and structured lipid on intestinal microbiota, colonic short chain fatty acid composition and serum lipid profiles in vivo
In this study, the effects of sea buckthorn oil (SBO), fish oil (FO) and an enzymatically synthesized structured lipid (SL) on serum, short-chain...
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5α-Epoxyalantolactone from Inula macrophylla attenuates cognitive deficits in scopolamine-induced Alzheimer’s disease mice model
Alzheimer’s disease (AD) is a complex neurodegenerative condition. 5 α -epoxyalantolactone (5 α -EAL), a eudesmane-type sesquiterpene isolated from the...
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Minimum inhibitory concentrations of aztreonam–avibactam, ceftazidime–avibactam and meropenem in clinical isolates of Klebsiella pneumoniae harboring carbapenemase genes
This study was aimed at understanding the distributions of the MICs (minimum inhibitory concentrations) of aztreonam–avibactam, ceftazidime–avibactam...
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Actinoplanes kirromycinicus sp. nov., isolated from soil
A novel actinomycete, designated as TPMA0078 T , was isolated from a soil sample collected in Shinjuku, Tokyo, Japan. 16S rRNA gene sequence analysis...
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Geministatins: new depside antibiotics from the fungus Austroacremonium gemini
Two new depside antibiotics, geministatins A ( 1 ) and B ( 2 ), were isolated from the fungus Austroacremonium gemini MST-FP2131 ( Sordariomycetes , Ascomycota...
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Identification of novel antistaphylococcal hit compounds
Staphylococcus aureus is one of the most common nosocomial biofilm-forming pathogens worldwide that has developed resistance mechanisms against...
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Synthesis and biochemical characterization of naphthoquinone derivatives targeting bacterial histidine kinases
Waldiomycin is an inhibitor of histidine kinases (HKs). Although most HK inhibitors target the ATP-binding region, waldiomycin binds to the...
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Inhibition of the ATP synthase increases sensitivity of Escherichia coli carrying mcr-1 to polymyxin B
Bacterial infections caused by multidrug-resistant (MDR) gram-negative strains carrying the mobile colistin resistance gene mcr-1 are serious threats...
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Two new aromatic tenvermectins from mutant Streptomyces avermitilis HU02-06
Two new aromatic tenvermectins (TVMs), 13-oleandrosyl-oleandrosyloxy ST906 ( 1 ) and aromatic TVM B ( 2 ), were isolated from the fermentation broth of Str...
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Ceftazidime is a potential drug to inhibit cell proliferation by increasing cellular p27
The development of new therapeutic uses for existing drugs is important for the treatment of some diseases. Cephalosporin antibiotics stand as the...
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Metabolite profiles of Paragliomastix luzulae (formerly named as Acremonium striatisporum) KMM 4401 and its co-cultures with Penicillium hispanicum KMM 4689
The marine holothurian-derived fungal strain KMM 4401 has been identified as Paragliomastix luzulae using 28S rDNA, ITS regions and the partial TEF1 ...
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Anti-MRSA activity of chlorophenyl pyrrolo benzodiazepines compound
Antibiotic resistant is the major concern in public health to control the infectious diseases. MRSA (Methicillin-resistant Staphylococcus aureus ) is...
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Synthesis and antibacterial action of 3’,6’-disubstituted spectinomycins
Spectinomycin is an aminocyclitol antibiotic with a unique ribosomal binding site. Prior synthetic modifications of spectinomycin have enhanced...
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Reversal of carbapenem resistance in Pseudomonas aeruginosa by camelid single domain antibody fragment (VHH) against the C4-dicarboxylate transporter
Antimicrobial resistance is emerging as the new healthcare crisis necessitating the development of newer classes of drugs using non-traditional...
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From inside to outside: exploring extracellular antimicrobial histone-derived peptides as multi-talented molecules
The emergence of bacterial resistance to antibiotics poses a global health threat, necessitating innovative solutions. The contemporary challenge...
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Cell morphology as biomarker of carbapenem exposure
Characterizing the physiological response of bacterial cells to antibiotics is crucial for designing diagnostic techniques, treatment choices, and...