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Targeting oncogene-induced cellular plasticity for tumor therapy
Cellular plasticity, the remarkable adaptability of cancer cells to survive under various stress conditions, is a fundamental hallmark that...
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Building a translational cancer dependency map for The Cancer Genome Atlas
Cancer dependency maps have accelerated the discovery of tumor vulnerabilities that can be exploited as drug targets when translatable to patients....
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Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health
Glutamine and glutamate are interconverted by several enzymes and alterations in this metabolic cycle are linked to cardiometabolic traits. Herein,...
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Cattleya attenboroughiana (Orchidaceae: Laeliinae): a new species from the Diamantina Plateau, Minas Gerais, Brazil
A new species of Cattleya ser. Parviflorae (Orchidaceae) is here described from the campos rupestres of the Diamantina Plateau, part of the Espinhaço...
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p53 at the crossroads of tumor immunity
The p53 tumor suppressor protein has a plethora of cell-intrinsic functions and consequences that impact diverse cell types and tissues. Recent...
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Long-term biotic homogenization in the East African Rift System over the last 6 million years of hominin evolution
Eastern Africa preserves the most complete record of human evolution anywhere in the world but we have little knowledge of how long-term...
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The autophagy adaptor TRIAD3A promotes tau fibrillation by nested phase separation
Multiple neurodegenerative diseases are characterized by aberrant proteinaceous accumulations of tau. Here, we report a RING-in-between-RING-type E3...
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Zeb1 mediates EMT/plasticity-associated ferroptosis sensitivity in cancer cells by regulating lipogenic enzyme expression and phospholipid composition
Therapy resistance and metastasis, the most fatal steps in cancer, are often triggered by a (partial) activation of the epithelial–mesenchymal...
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Dihydroorotase MoPyr4 is required for development, pathogenicity, and autophagy in rice blast fungus
Dihydroorotase (DHOase) is the third enzyme in the six enzymatic reaction steps of the endogenous pyrimidine nucleotide de novo biosynthesis pathway,...
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First Record of Telenomus dilophonotae (Hymenoptera, Scelionidae), Parasitizing Eggs of Erinnyis ello (Lepidoptera, Sphingidae) in Western Paraná, Brazil, with Molecular Characterization and Records of Occurrences
There are few records for Telenomus dilophonotae Cameron, 1913 (Hymenoptera, Scelionidae) from South America. In Brazil, the first occurrence was...
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Discovery of a novel hybrid coumarin-hydroxamate conjugate targeting the HDAC1-Sp1-FOSL2 signaling axis for breast cancer therapy
BackgroundBreast cancer is one of the most lethal cancers in women. Despite significant advances in the diagnosis and treatment of breast cancer,...
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Heritability and correlations for honey yield, handling ease, brood quantity, and traits related to resilience in a French honeybee population
There is growing interest in selective breeding of the honeybee, resulting in the emergence of new breeding projects, often with an emphasis on...
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Enzymatic activity assays and functional component profiling reveals coordinated defense response of mungbean against Cercospora canescens during leaf spot disease
Cercospora leaf spot (CLS) caused by Cercospora canescens is a formidable seed-borne disease and survives in crop debris or other host plants...
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In planta production of human-derived RANKL
RANKL (Receptor Activator of Nuclear Factor Kappa-B Ligand) is a cytokine that plays a crucial role in bone remodeling by regulating differentiation...
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DAP12 interacts with RER1 and is retained in the secretory pathway before assembly with TREM2
DNAX-activating protein of 12 kDa (DAP12) is a transmembrane adapter protein expressed in lymphoid and myeloid lineage cells. It interacts with...
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Transcriptomic profiling and discovery of key transcription factors involved in adventitious roots formation from root cuttings of mulberry
ARs plays a crucial role in plant morphogenesis and development. The limited and inefficient rooting of scions poses a significant challenge to the...
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ESF1 and MIPEP proteins promote estrogen receptor-positive breast cancer proliferation and are associated with patient prognosis
BackgroundEstrogen receptor-positive (ER+) breast cancer accounts for two-thirds of all breast cancers, and its early and late recurrences still...
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Vitamin C inactivates c-Jun N-terminal kinase to stabilize heart and neural crest derivatives expressed 1 (Hand1) in regulating placentation and maintenance of pregnancy
Vitamin C (VC) serves as a pivotal nutrient for anti-oxidation process, metabolic responses, and stem cell differentiation. However, its precise...
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Exploring the challenges of RNAi-based strategies for crop protection
RNA silencing (or RNA interference, RNAi) initiated by double-stranded RNAs is a conserved mechanism for regulating gene expression in eukaryotes....
